Retinol supplementation may lower melanoma risk

Maryam M. Asgari, M.D., M.P.H., of Kaiser Permanente Northern California in Oakland, and colleagues evaluated data from 69,635 adults who participated in the VITamins And Lifestyle (VITAL) cohort study to determine whether there was an association between dietary and supplemental vitamin A and carotenoid intake and melanoma risk.

In the 5.84 years of follow-up, the researchers identified 566 incident melanomas. Baseline use of retinol supplements correlated with a significant decrease in the risk of melanoma (hazard ratio [HR], 0.60). Compared with nonusers, adults who took high-dose retinol supplements (>1,200 µg per day) had a significantly lower risk of melanoma (HR, 0.74), particularly in areas of the body exposed to the sun. Dietary or total intake of vitamin A or carotenoids, however, was not associated with a reduced risk of melanoma.

"Our data, which are based on a large prospective cohort, suggest that retinol intake from individual supplements is associated with a reduction in risk for melanoma, especially among women. Our findings suggest that vitamin A supplementation may hold promise as a chemopreventive agent for melanoma," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Journal reference: Journal of Investigative Dermatology

Copyright © 2012 HealthDay. All rights reserved.