Increasing shift from islet antibody positivity to diabetes

Increasing shift from islet antibody positivity to diabetes

(HealthDay) -- There is an increase in both the prevalence and levels of islet antigen-2 and zinc transporter 8, as well as in autoantibodies, in newly diagnosed type 1 diabetes patients during a period of rising disease incidence, according to a study published in the March issue of Diabetes.

Anna E. Long, of the University of Bristol in the United Kingdom, and colleagues analyzed autoantibodies to insulin (IAA), (GADA), islet antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A) by measurement with radioimmunoassay of sera collected from children and young adults with newly diagnosed between 1985 and 2002.

The researchers found that the prevalence of IA-2A and ZnT8A increased significantly over the period studied. This finding was accompanied by raised levels of IA-2A, ZnT8A, and IA-2β autoantibodies (IA-2βA). No changes were observed in IAA or GADA prevalence and levels.

"Increases in IA-2A, ZnT8A, and IA-2βA at diagnosis during a period of rising incidence suggest that the process leading to type 1 diabetes is now characterized by a more intense humoral autoimmune response," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

G299.2-2.9, a middle-aged supernova remnant

Oct 13, 2011

(PhysOrg.com) -- G299.2-2.9 is an intriguing supernova remnant found about 16,000 light years away in the Milky Way galaxy. Evidence points to G299.2-2.9 being the remains of a Type Ia supernova, where a white ...

New clues to pancreatic cells' destruction in diabetes

Feb 03, 2009

Researchers have found what appears to be a major culprit behind the loss of insulin-producing β cells from the pancreases of people with diabetes, a critical event in the progression of the disease.

Dramatic increase of Type 1 diabetes in under fives

Mar 16, 2007

Researchers are calling for more work in to the reasons behind a big increase of young children with Type 1 diabetes. A new study, led by Bristol University, has discovered that the number of children under five-years-old ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.