Tibial trabecular bone texture predicts osteoarthritis progression

Tibial trabecular bone texture predicts OA progression

(HealthDay) -- Changes in medial and lateral trabecular bone texture can predict joint space narrowing (JSN) and progression of knee osteoarthritis (OA), according to research published in the March issue of Arthritis & Rheumatism.

To evaluate OA progression based on an increase in the medial JSN grade, Tom Woloszynski, of the University of Western Australia in Perth, and associates used two sets of knee radiographs from 105 individuals obtained four years apart to calculate three texture parameters of the medial and lateral compartment tibial trabecular bone in 203 with (68) or without (135) preexisting radiographic tibiofemoral OA .

The researchers found that, in knees with or without preexisting radiographic OA, medial trabecular bone texture predicted increased medial JSN in knees with and without OA, with an area under the curve (AUC) of 0.77 and 0.75, respectively. In knees with and without preexisting OA, the AUC for lateral trabecular bone texture was 0.71 and 0.72, respectively.

"We have developed a system, based on analyzing tibial trabecular bone texture, which yields good prediction of loss of tibiofemoral joint space," the authors write. "The predictive ability of the system needs to be further validated."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Ontario has one of the highest rates of IBD in the world

Aug 28, 2014

One in every 200 Ontarians has been diagnosed with inflammatory bowel disease (IBD), with the number of people living with the disease increasing by 64 per cent between 1999 and 2008, according to a study by researchers at ...

New drug promises relief for inflammatory pain

Aug 27, 2014

Pain from inflammation sidelines thousands of Americans each year. Many face a tough choice: deal with the pain, take a potentially addictive opioid or use a nonsteroidal anti-inflammatory drug that may increase risk for ...

Overweight causes hazardous inflammations

Aug 25, 2014

Researchers have found a possible molecular explanation for why overweight is harmful. This new knowledge may provide new drugs for heart attack, stroke, cancer and chronic intestinal inflammation.

Asthma outcomes worse in older women

Aug 21, 2014

(HealthDay)—Older women face increased challenges in managing their asthma, according to a review published in the August issue of the Annals of Allergy, Asthma & Immunology.

User comments