Von Willebrand factor linked to bleeding complications

Von willebrand factor linked to bleeding complications

(HealthDay) -- Oral anticoagulation (OAC)-treated patients with high levels of von Willebrand factor (VWF) have elevated risks of bleeding complications and cardiovascular and all-cause mortality, according to a study published in the March issue of the Journal of Internal Medicine.

Marcus Lind, M.D., of Umeå University Hospital in Sweden, and associates conducted a longitudinal study of 719 receiving OAC treatment to evaluate the link between VWF plasma levels and risk of bleeding complications, cardiovascular death, and all-cause mortality.

During 4.2 years of follow-up, the researchers identified 113 cases of clinically relevant bleeding and 73 cases of major bleeding; and there were 161 deaths, including 110 attributed to cardiovascular disease. There was a significantly increased risk of bleeding complications for patients in the highest tertile of VWF (hazard ratio [HR] for major bleeding, 2.53; HR for clinically relevant bleeding, 2.19). VWF was significantly associated with cardiovascular and all-cause mortality (HR, 1.68 and 1.77, respectively). These findings were significant after adjusting for age, high-sensitivity C-reactive protein, and creatinine.

"Our findings imply that the use of VWF as a risk marker for thromboembolic events is complicated by the association of VWF with ," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

New study shows patients with coronary artery disease

Aug 30, 2011

Thrombotic (clotting) and bleeding events are complications that may occur after surgery. With the aging population in the western world, there are more patients undergoing orthopedic surgery than ever before. This makes ...

Evolution provides clue to blood clotting

Jul 20, 2011

A simple cut to the skin unleashes a complex cascade of chemistry to stem the flow of blood. Now, scientists at Washington University School of Medicine in St. Louis have used evolutionary clues to reveal ...

Even low-dose aspirin may increase risk of GI bleeding

Sep 12, 2011

The risk of gastrointestinal (GI) bleeding needs to be considered when determining the potential preventive benefits associated with low-dose aspirin for cardiovascular disease and cancer. According to a new study in Clinical Ga ...

Recommended for you

Post-PCI bleeding rates vary widely across hospitals

17 hours ago

(HealthDay)—Patient case-mix and procedural factors may contribute to wide variation in the hospital rates of bleeding after percutaneous coronary intervention (PCI), according to research published online ...

Most seniors eligible for statin Rx under new guidelines

Nov 25, 2014

(HealthDay)—Most older Americans qualify for treatment with statins under new guidelines for the treatment of blood cholesterol released late last year by the American College of Cardiology and the American ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.