ACR endorses standardized measures to determine rheumatoid arthritis disease activity
A working group convened by the American College of Rheumatology (ACR) has evaluated more than 60 disease activity measures for rheumatoid arthritis (RA). The group narrowed the number of RA disease activity measures and the recommended six for use in U.S. clinical practice are detailed in Arthritis Care & Research, a journal published by Wiley-Blackwell on behalf of the ACR.
RA is a systemic inflammatory disease, affecting more than 1 million Americans according to ACR estimates. Medical evidence has shown significant improvement in RA treatment over the last two decades, making disease remission possible for many patients. While many health care stakeholders advocate standardized assessments for RA disease activity, uniform measures of RA activity are not currently used by U.S. rheumatologists.
To address this important issue, the RA Clinical Disease Activity Measures Working Group systematically reviewed medical literature to identify disease activity measures for RA. The group surveyed rheumatologists for input and used this feedback along with psychometric analysis to determine recommendations for RA disease activity assessments.
"Our goal was to determine which RA disease activity measures could accurately distinguish the various levels of RA activity, and would also be reasonable to implement in clinical practice," explains Salahuddin Kazi, M.D., with Dallas VA Medical Center in Texas and one of the lead researchers involved with the working group. The group identified 63 RA disease activity measures, narrowing that down to 14 measures for further evaluation by practicing rheumatologists.
Feedback from the rheumatologists determined that 9 measures would be most useful and feasible in a clinical setting. The working group then selected 6 disease activity measures based on their reliability, validity and responsiveness. The ACR-approved recommendations for RA disease activity measures include:
- Clinical Disease Activity Index (CDAI)
- Disease Activity Score with 28-joint counts (erythrocyte sedimentation rate or C-reactive protein) (DAS-28)
- Patient Activity Scale (PAS)
- Routine Assessment of Patient Index Data with 3 measures (RAPID 3)
- Simplified Disease Activity Index (SDAI)
The measures recommended to determine RA disease activity are sensitive to change, can discriminate between low, moderate, and high disease activity states, include remission criteria, and are feasible to perform in a clinical setting," concludes Dr. Kazi. "Incorporating standardized disease activity measures will facilitate adherence to the ACR guidelines for treating RA and aid clinicians in providing quality care to their patients with RA."
More information: Rheumatoid Arthritis Disease Activity Measures: American College of Rheumatology Recommendations for Use in Clinical Practice." Jaclyn Anderson, Liron Caplan, Jinoos Yazdany, Mark L. Robbins, Tuhina Neogi, Kaleb Michaud, Kenneth G. Saag, James R. O'Dell and Salahuddin Kazi. Arthritis Care & Research; Published Online: April 2, 2012 (DOI: 10.1002/acr.21649).
Provided by Wiley
- Achieving realistic physical activity goals benefits RA patients Aug 25, 2011 | not rated yet | 0
- Rheumatoid arthritis researchers redefine remission Feb 03, 2011 | not rated yet | 0
- 2 in 5 adults with rheumatoid arthritis are physically inactive Jan 26, 2012 | not rated yet | 0
- Rheumatoid arthritis: Worse in women? Jan 14, 2009 | not rated yet | 0
- Study shows RA patients and doctors differ on disease severity assessment May 25, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Force Between Two Concentric Solenoids
2 hours ago Imagine a finite length solenoid with outer radius R1 and inner radius R2. This solenoid has a time-varying current going though it. This solenoid is...
Synchrotron, question about insertion devices and electron velocity
3 hours ago When an electron enters an insertion device (wiggler and undulator) from the storage ring in a synchrotron the tangential velocity is equal to the...
Equating differentials => equating coefficients
4 hours ago Hi all, In thermodynamics one often has equations like A dx + B dy = ∂f/∂x dx + ∂f/∂y dy From which follows A = ∂f/∂x B = ∂f/∂y
The idea behind a reverse shock
10 hours ago So in a supernova explosion for example (5th slide) http://www.astro.princeton.edu/~burrows/classes/541/blastwavesChisari.pdf Ambient medium is...
Guass's Law for a charge distribution
10 hours ago First, this is not a homework question, just something I've been confused about for some time. I understand how to use Guass's law in many ways but...
11 hours ago Hello :) i'm new to this forum, so excuse me for my straightforwardness ;) I'm working on my bachelor work and i can't find a solution. I'm writing...
- More from Physics Forums - Classical Physics
More news stories
(Medical Xpress)—UCD researchers led by Conway Fellow, Professor David Brayden in UCD School of Veterinary Medicine have successfully reduced inflammation in the swollen arthritic knees of a murine model using a novel nanoparticle.
Arthritis & Rheumatism May 24, 2013 | 5 / 5 (1) | 0
In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe ...
Arthritis & Rheumatism May 22, 2013 | 5 / 5 (3) | 0 |
(HealthDay)—Injections of a sugar solution appear to help relieve knee pain and stiffness related to osteoarthritis, a new study suggests.
Arthritis & Rheumatism May 21, 2013 | 4.5 / 5 (2) | 0 |
A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings from the Framingham Foot ...
Arthritis & Rheumatism May 20, 2013 | not rated yet | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
Arthritis & Rheumatism May 19, 2013 | 4.9 / 5 (8) | 0 |
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
16 hours ago | 5 / 5 (2) | 5
(HealthDay)—Animals make great companions for senior citizens, but elderly people who always drive with a pet in the car are far more likely to crash than those who never drive with a pet, researchers have ...
7 hours ago | not rated yet | 1
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
15 hours ago | not rated yet | 1
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
15 hours ago | not rated yet | 0
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
15 hours ago | not rated yet | 0