Improving equine health: Research studies vaccinations to protect newborn foals

April 4, 2012

A Kansas State University veterinary medicine student is investigating ways to improve horse vaccinations and defend them against pathogen challenges at an early age.

Research from Allison Jordan Bryan, a graduate student in and a second-year student, Huntington Beach, Calif., may help protect foals as young as 3 months of age from pathogens such as , tetanus, equine influenza virus, Equine Herpes Virus-1, Eastern equine encephalomyelitis and Western equine encephalomyelitis.

"It is important, especially in the equine world, to vaccinate the foals as soon as possible so they will be protected against environmental pathogens they may come into contact with, even at an early age," Bryan said.

Bryan recently received a second place award at the K-State Research Forum for her oral research presentation titled "Characterization of in healthy foals when vaccination is initiated at 3 months of age."

Foals acquire maternal antibodies and that help protect them from environmental pathogens before they can fully develop their own immune systems, Bryan said. Newborn foals acquire these maternal antibodies and cells through ingestion and absorption of colostrum.

Foals are usually vaccinated at 6 months of age, which gives time for maternal antibodies to decline so they do not interfere with any vaccines. But Bryan is looking at the possibility of vaccinating foals at 3 months of age -- the earlier age is better because it gives foals more protection against pathogens earlier in life.

"We're trying to determine whether those are still in high enough concentration at 3 months to interfere with vaccines and block the active immune response or to see if these antibodies have waned enough to allow a robust immune response," Bryan said.

Bryan is still collecting and analyzing data. Preliminary data has indicated an in 3-month-old foals, making it possible to vaccinate foals at a younger age and increase protection.

Although Bryan has always been interested in the , she got involved with equine research after spending a summer in the university's Veterinary Research Scholars Program, which is funded by the National Institutes of Health, or NIH, and Merial, a worldwide animal health company.

Bryan is now participating in the NIH-funded Basic Research Immersion Training Experience, or BRITE, program. Her faculty advisers are Elizabeth Davis, associate professor of clinical sciences, and Melinda Wilkerson, professor of diagnostic medicine and pathobiology.

"Jordan is a talented individual who has a very bright future in the field of biomedical research," Davis said. "In the past year she has gained knowledge and skills that will help her with her future investigative endeavors. It has been a pleasure to have her as a graduate student in our program."

"The mentorship and guidance has made it a wonderful experience and I will definitely pursue a career in research following completion of my veterinary degree," Bryan said. "I have been very fortunate to work with extremely talented individuals at K-State and am honored to be a part of the research community here at K-State."

Related Stories

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.