Erosive, but not nonerosive, GERD ups esophageal CA risk

(HealthDay) -- Patients with gastroesophageal reflux disease with a history of esophagitis are at increased risk for esophageal adenocarcinoma, although the absolute risk is low, according to a study published in the May issue of Clinical Gastroenterology and Hepatology.

Rune Erichsen, M.D., from Aarhus University in Denmark, and colleagues analyzed data from 33,849 patients with reflux disease (52 percent men; median age, 59.3 years) identified in population-based Danish medical registries from 1996 to 2008. The observed incidence among patients with erosive and nonerosive disease was compared with the expected incidence for the general population.

The researchers found that 77 percent of participants (26,194) had erosive reflux disease, and over a mean follow-up of 7.4 years, 37 subsequently developed esophageal adenocarcinoma. After 10 years, the absolute risk was 0.24 percent. Compared with the expected incidence for the general population, the observed incidence among patients with erosive reflux disease was significantly increased (standardized incidence ratio, 2.2). After 4.5 years of follow-up, only one patient out of 7,655 patients with nonerosive reflux disease was diagnosed with esophageal adenocarcinoma (standardized incidence ratio, 0.3).

"Erosive reflux disease, but not nonerosive disease, increased the risk of esophageal adenocarcinoma, based on analysis of population-based Danish medical registries," the authors write. " therefore might be an important factor in the progression from reflux to esophageal adenocarcinoma."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Obesity linked to acid reflux disease

Dec 12, 2006

According to a new article in The American Journal of Gastroenterology, gastroesophageal reflux disease (GRD), more commonly known as, acid reflux, is linked to obesity. Since (GRD) is strongly associated with more seriou ...

Recommended for you

Can robots help stop the Ebola outbreak?

6 hours ago

The US military has enlisted a new germ-killing weapon in the fight against Ebola—a four-wheeled robot that can disinfect a room in minutes with pulses of ultraviolet light.

New bird flu case in Germany

6 hours ago

A worrying new strain of bird flu has been observed for the first time in a wild bird in northern Germany, the agriculture ministry said Saturday.

Mali announces new Ebola case

Nov 22, 2014

Mali announced Saturday a new case of Ebola in a man who is fighting for his life in an intensive care unit in the capital Bamako.

Plague outbreak kills 40 in Madagascar: WHO

Nov 22, 2014

An outbreak of plague has killed 40 people in Madagascar, the World Health Organization said, warning that the disease could spread rapidly in the country's densely populated capital Antananarivo.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.