Smoking found to be a risk factor for Barrett's esophagus

April 11, 2012
Smoking found to be a risk factor for barrett's esophagus
Cigarette smoking may be a modifiable risk factor for Barrett's esophagus, according to a study published in the April issue of Gastroenterology.

(HealthDay) -- Cigarette smoking may be a modifiable risk factor for Barrett's esophagus, according to a study published in the April issue of Gastroenterology.

To investigate the association between cigarette smoking and Barrett's esophagus, Michael B. Cook, Ph.D., of the in Bethesda, Md., and associates analyzed data from five case-control studies within the international Barrett's and Consortium. Data were compared for 1,059 patients with Barrett's esophagus, 1,332 controls with (GERD), and 1,143 population-based controls.

The researchers found that patients with Barrett's esophagus were significantly more likely to have ever smoked cigarettes than the population-based control group or the GERD cohort (odds ratio, 1.67 and 1.61, respectively). There was an increased risk of Barrett's esophagus with increasing pack-years of smoking. Among individuals who ever smoked and had heartburn or regurgitation, the attributable proportion of disease was estimated at 0.39.

"Cigarette smoking is a risk factor for Barrett's esophagus," the authors conclude. "The evidence we present for a biological interaction between smoking and heartburn/regurgitation suggest that cigarette smoking has multifaceted effects in the development of this precancerous metaplasia."

Explore further: Barrett's esophagus carries lower risk of malignancy than previously reported

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Cellphone data can track infectious diseases

August 20, 2015

Tracking mobile phone data is often associated with privacy issues, but these vast datasets could be the key to understanding how infectious diseases are spread seasonally, according to a study published in the Proceedings ...

Could flu someday be prevented without a vaccine?

August 11, 2015

Researchers have discovered a way to trigger a preventive response to a flu infection without any help from the usual players - the virus itself or interferon, a powerful infection fighter.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.