Genes that promote cartilage healing protect against arthritis
In mice with ears that heal rapidly, cartilage (shown in the thick blue border) also regenerates and heals more quickly. Washington University researchers found that the same genes that promote healing after cartilage damage also appear to protect against osteoarthritis. (SANDELL LABORATORY)
(Medical Xpress) -- The same genes that promote healing after cartilage damage also appear to protect against osteoarthritis, a condition caused by years of wear-and-tear on the cartilage between joints, new research at Washington University School of Medicine in St. Louis shows.
Our goal is to see whether we can protect cartilage in people by detecting the early biological changes that occur in osteoarthritis and prevent it from progressing to the stage where joint replacement becomes necessary, says principal investigator Linda J. Sandell, PhD, the Mildred B. Simon Professor of Orthopaedic Surgery. The main problem with biological treatments is that currently, we cant detect osteoarthritis in its early stages. Better understanding of the genes that influence the disorder may help us do that.
The researchers reported their findings in a pair of studies, published online in the journals Arthritis & Rheumatism and Osteoarthritis and Cartilage.
Osteoarthritis is the most common form of arthritis, affecting 25 million people in the United States. It is linked to the breakdown of cartilage, which acts as a shock absorber to cushion the joints. Osteoarthritis causes pain, swelling and reduced motion and is most common in the hands, knees, hips or spine.
This video is not supported by your browser at this time.Scientists first discovered cartilage-healing properties in some strains of laboratory mice when they pierced their ears as a means to tag and identify them. But in some mice, the holes in their ears closed and quickly healed. Because so much of the ear is made from cartilage and healing occurred so rapidly in the mice ears, the researchers suspected that these mice also may be able to regenerate cartilage in their joints.
Sandell and her team bred the mice that healed rapidly with other mice that healed more slowly, and they found that the mice that could quickly heal and regenerate cartilage in the knee also were less susceptible to osteoarthritis.
In people, a breakdown of cartilage causes the bones to rub together and damage the joint. If the damage becomes too extensive, joint replacement surgery may be necessary.
Injury to a joint is a major risk factor for osteoarthritis, but not everyone is equally susceptible.
Some people and these mouse studies suggest that someday we may be able to predict which people fare much better after an injury, Sandell says. We want to find a way to identify the genes that protect them.
Sandell, director of the universitys Core Center for Musculoskeletal Biology and Medicine, and co-investigator James M. Cheverud, PhD, professor of anatomy and neurobiology, now are studying several other strains of mice on the spectrum between the good healers and those that heal poorly. Theyve looked at the cartilage tissue under the microscope to determine the extent of osteoarthritis following an injury and analyzed the DNA in cartilage.
Weve identified genes that correlate with healing and with protection from osteoarthritis, Sandell says. The work is in its beginning stages, but now that weve found a correlation, we want to look at even more strains of mice so that we can actually map the location of the genes that cause osteoarthritis and help to repair cartilage.
She says osteoarthritis, like several other disorders, will ultimately involve many genes that each contribute in a small way to the disease process. By looking at more strains of mice, the research team believes it will become easier to identify the subtle genetic influences on osteoarthritis risk. As they clarify which genes are protecting the mice, it will be possible to look for similar genes in humans.
More information: Rai MF, Hashimoto S, Johnson EE, Janiszak KL, Fitzgerald J, Heber-Katz E, Cheverud JM, Sandell LJ. Heritability of articular cartilage regeneration and its association with ear-wound healing. Arthritis & Rheumatism, vol. 64 (published online). DOI 10.1002/art.34396
Hashimoto S, Rai MF, Janiszak KL, Cheverud JM, Sandell LJ. Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice. Osteoarthritis and Cartilage, vol. 20 (published online). doi: 10.1016/j.joca.2012.01.022
- Research team finds compound that can spur cartilage growth Apr 06, 2012 | not rated yet | 0
- Scientists find cause of cartilage degeneration in osteoarthritis Jan 12, 2009 | not rated yet | 0
- Progress in tissue engineering to repair joint damage in osteoarthritis Jun 08, 2011 | not rated yet | 0
- 'Lubricin' molecule discovered to reduce cartilage wear Oct 21, 2010 | not rated yet | 0
- Glucocorticoid treatment may prevent long-term damage to joints Sep 02, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
the rudyak-krasnolutski effective potencial
42 minutes ago Hi ... anyone now how to calculate or the formula of the rudyak-krasnolutski EFFECTIVE potencial ? the effective potencial includes the angular...
Normal force for a lever model
2 hours ago My model is a lever on a table top. One arm is horizontal on the table, while the other arm is raised at an angle alpha. I'm assuming the weight of...
gravity is std. therefore can we rate a 'mass at height' by watts?
7 hours ago For example.... wind turbines are primarily listed by their wattage (1.5MW etc.) Presumably their output is varied according to rotational speed, so...
Calculating on-axis elements of a solenoid
19 hours ago I wanted to mention that this solenoid has many winds over many layers. The thickness of the windings is 2.4 inches coming off of the engineering...
latitude & longitude & air pressure
20 hours ago Hi there, I have a peculiar question. Imagine that you are in a earth position, obtained by google, that gives you the latitude and longitude....
Differences of Classical Mechanics when learned with Calc vs algebra?
23 hours ago what are the differences? Every example I find usually has a derivative or integral or some kind of calculus defined concept that seems to make it...
- More from Physics Forums - Classical Physics
More news stories
In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe ...
Arthritis & Rheumatism May 22, 2013 | 5 / 5 (2) | 0 |
(HealthDay)—Injections of a sugar solution appear to help relieve knee pain and stiffness related to osteoarthritis, a new study suggests.
Arthritis & Rheumatism May 21, 2013 | 4.5 / 5 (2) | 0 |
A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings from the Framingham Foot ...
Arthritis & Rheumatism May 20, 2013 | not rated yet | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
Arthritis & Rheumatism May 19, 2013 | 4.9 / 5 (8) | 0 |
(HealthDay)—Compared to clinical diagnosis of synovitis, ultrasound-detected synovitis provides either improved sensitivity or specificity when used with the American College of Rheumatology/European League ...
Arthritis & Rheumatism May 15, 2013 | not rated yet | 0
Ethnic background plays a surprisingly large role in how diabetes develops on a cellular level, according to two new studies led by researchers at the Stanford University School of Medicine.
18 minutes ago | not rated yet | 0 |
Cinnamon: Can the red-brown spice with the unmistakable fragrance and variety of uses offer an important benefit? The common baking spice might hold the key to delaying the onset of –– or warding off ...
39 minutes ago | not rated yet | 0 |
Chinese and U.S. scientists have used virus isolated from a person who died from H7N9 avian influenza infection to determine whether the virus could infect and be transmitted between ferrets. Ferrets are often used as a mammalian ...
1 hour ago | not rated yet | 0 |
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
41 minutes ago | not rated yet | 0 |
UCLA researchers examining outcomes for advanced heart-failure patients over the past two decades have found that, coinciding with the increased availability and use of new therapies, overall mortality has decreased and sudden ...
44 minutes ago | not rated yet | 0
Aortic arch pulse wave velocity, a measure of arterial stiffness, is a strong independent predictor of disease of the vessels that supply blood to the brain, according to a new study published in the June issue the journal ...
45 minutes ago | not rated yet | 0