Intestinal macrophages in liver cirrhosis produce NO, disrupt intestinal barrier function
April 19, 2012 in Diseases, Conditions, Syndromes
A South African study presented today determines the importance of bacterial infections, which commonly occur in cirrhosis and can alter the natural history of the condition, possibly leading to loss of liver function and decompensation. It is now recognised that many infections in cirrhotic patients result from bacterial translocation (BT) from the intestine.
Results show the presence of activated CD14+Trem-1+iNOS+ intestinal macrophages, as well as increased levels of NO, IL-6 and claudin-2 levels in the duodenum of patients with decompensated liver cirrhosis.(1) The data suggests these observed factors enhance intestinal permeability of bacterial products.
Increased plasma LPS levels were observed, as well as increased numbers of activated duodenal macrophages expressing CD33+/CD14+/Trem-1+, synthesising iNOS and functionally secreting NO.
Upregulation at the mRNA level of IL-8, CCL-2, CCL-13, NOS2 was found. Increased levels of IL-8 and IL-6 levels were detected in the serum and culture supernatant of patients with cirrhosis.
The epithelial barrier was not structurally altered by electron microscopy but increased expression of the "pore"-forming tight junction claudin-2 levels were detected by western blot.
More information: du Plessis J, Activated intestinal macrophages in liver cirrhosis produce nitric oxide and disrupt intestinal barrier function. Abstract presented at the International Liver Congress 2012
Provided by European Association for the Study of the Liver
-
IL-32 expression upregulated in chronic rhinosinusitis
Apr 17, 2012 |
not rated yet |
0
-
Vitamin D deficiency in cirrhosis
Mar 15, 2011 |
not rated yet |
0
-
Risk of death increases in IBD patients with hospital-acquired infections
Nov 30, 2010 |
not rated yet |
0
-
Intestinal bacteria associated with nonalcoholic fatty liver disease
May 29, 2009 |
not rated yet |
0
-
Study suggests obesity accelerates progression of cirrhosis
Jul 21, 2011 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011
- More from Physics Forums - Independent Research
More news stories
Saudi to send animal samples to US in coronavirus probe
Saudi Arabia said Friday it would send samples taken from animals possibly infected with a deadly SARS-like virus to the United States for testing in a bid to find the source of disease.
Diseases, Conditions, Syndromes
2 hours ago |
not rated yet |
0
WHO voices deep concern over spread of SARS-like virus
The World Health Organization voiced deep concern Thursday over the SARS-like virus that has killed 22 people in less than a year, saying it might potentially spread more widely between humans.
Diseases, Conditions, Syndromes
5 hours ago |
5 / 5 (1) |
0
WHO: Scientific red tape mars efforts vs. virus
International efforts to combat a new pneumonia-like virus that has now killed 22 people are being slowed by unclear rules and competition for the potentially profitable rights to disease samples, the head ...
Diseases, Conditions, Syndromes
18 hours ago |
not rated yet |
0
Shortage of key drug hampering U.S. efforts to control TB, report says
(HealthDay)—A shortage of a critical tuberculosis drug has hampered the efforts of health departments across the United States to contain the spread of the highly infectious lung disease, federal officials ...
Diseases, Conditions, Syndromes
18 hours ago |
not rated yet |
0
Heart healthy lifestyle may cut kidney disease patients' risk of kidney failure
Maintaining a heart healthy lifestyle may also help protect chronic kidney disease patients from developing kidney failure and dying prematurely, according to a study appearing in an upcoming issue of the Journal of the Am ...
Diseases, Conditions, Syndromes
19 hours ago |
not rated yet |
0
Hormone levels may provide key to understanding psychological disorders in women
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
Going live: Immune cell activation in multiple sclerosis
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
ACOG: Hormone therapy not recommended to prevent CHD
(HealthDay)—Menopausal hormone therapy should not be used for prevention of coronary heart disease, according to a Committee Opinion from the American College of Obstetricians and Gynecologists (ACOG) published ...
Youth with type 2 diabetes at much higher risk for heart, kidney disease
The news about youth and diabetes keeps getting worse. The latest data from the national TODAY diabetes study shows that children who develop Type 2 diabetes are at high risk to develop heart, kidney and eye problems faster ...
New animal model gives insights into mechanisms of Parkinson's disease pathogenesis
In Parkinson's disease, the protein "alpha-synuclein" aggregates and accumulates within neurons. Specific areas of the brain become progressively affected as the disease develops and advances. The mechanism underlying this ...
Audiologists recommend smart phone apps to monitor noise levels
After studying noise in one French Quarter neighborhood of New Orleans to determine whether or not noise levels exceeded municipal ordinances, Annette Hurley, PhD, Assistant Professor of Audiology at LSU Health Sciences Center ...
