Japanese researchers show that acupuncture can improve skeletal muscle atrophy
A team of Japanese researchers will reveal study results Monday at the Experimental Biology 2012 meeting that show how acupuncture therapy mitigates skeletal muscle loss and holds promise for those seeking improved mobility through muscle rejuvenation.
"It is my hope that this study will demonstrate acupuncture's feasibility with regard to improving health among the elderly and medical patients. Our findings could identify acupuncture as the primary nonpharmacological treatment to prevent skeletal muscle atrophy in the future," says Akiko Onda, an acupuncturist and graduate student at the Waseda University School of Sport Sciences, who has been conducting a series of studies on skeletal muscle atrophy for the past four years. Her presentation will be on Monday, April 23, at the American Society for Biochemistry and Molecular Biology annual meeting, which is part of EB2012.
Loss of skeletal muscle mass has a profound effect on the ability of the elderly and the sick to engage in physical activity. Because skeletal muscle has high plasticity, interventions such as exercise training, improved nutrition and mechanical stimulation are often recommended to prevent atrophy. Unfortunately, these can be challenging goals for those who are already frail or who have severe medical conditions. Onda insists an alternative nonpharmacological intervention is urgently required, and so she and her collaborators in two labs at Waseda University decided to explore how acupuncture affects skeletal muscle at the molecular level.
"The main focus of this study is changes in the mRNA expression levels of muscle-specific atrophic genes such as atrogin-1," Onda says. "Muscle mass and structure are determined by the balance between protein degradation and synthesis."
The team showed that decreases in muscle mass in mice and in the mRNA expression level of the E3 ubiquitin ligase atrogin-1 can be significantly reversed by acupuncture.
In spite of the World Health Organization's endorsement of acupuncture and the widespread use of acupuncture as a treatment for various diseases, acupuncture is still regarded by many as obscure and suspicious, and its underlying molecular mechanisms are almost completely unknown.
"Our results have uncovered one molecular mechanism responsible for the efficacy of acupuncture treatment and clarified its usefulness in preventing skeletal muscle atrophy in mice," Onda said. "We hope to introduce acupuncture as a new strategy for preventing skeletal muscle atrophy in the future. Further investigations into its molecular mechanisms will help to decrease the medical community's suspicion of acupuncture and provide us with a better understanding of how acupuncture treatment prevents skeletal muscle atrophy."
Provided by American Society for Biochemistry and Molecular Biology
- Needles improve exercise tolerance in heart patients Jul 01, 2010 | not rated yet | 0
- Muscle atrophy through thick but not thin Jun 08, 2009 | not rated yet | 0
- Researchers discover target that could ease spinal muscular atrophy symptoms Jan 07, 2009 | not rated yet | 0
- Key finding in rare muscle disease Jan 17, 2007 | not rated yet | 0
- A natural hormone may protect muscle from atrophy Jun 11, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
New research from the University of Southampton has shown that blind and visually impaired people have the potential to use echolocation, similar to that used by bats and dolphins, to determine the location of an object.
Medical research 46 minutes ago | not rated yet | 0 |
A novel vaccine study from South Dakota State University (SDSU) will headline the groundbreaking research that will be unveiled at the American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference ...
Medical research 1 hour ago | not rated yet | 0
Every 20 seconds, a limb is lost as a consequence of diabetic foot ulcer that does not heal. To date, medical solutions that can change this situation are very limited. In his doctoral thesis Yue Shen from the Industrial ...
Medical research 5 hours ago | not rated yet | 0
When tumours metastasise, they can block lymphatic vessels, as researchers from ETH Zurich have discovered using a new method. The lymphatic fluid subsequently has to find a new path through the tissue. Such ...
Medical research 5 hours ago | not rated yet | 0 |
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
Medical research 23 hours ago | 5 / 5 (3) | 0 |
While the effects of acute stroke have been widely studied, brain damage during the subacute phase of stroke has been a neglected area of research. Now, a new study by the University of South Florida reports that within a ...
29 minutes ago | not rated yet | 0 |
A new report suggests that improved health care and significant reductions in drug costs might be attained by breaking up the age-old relationship between physicians and drug company representatives who promote the newest, ...
31 minutes ago | not rated yet | 0
Food microbiology laboratories continue to submit false negative results and false positive results on a routine basis. A retrospective study of nearly 40,000 proficiency test results over the past 14 years, presented today ...
17 minutes ago | not rated yet | 0
Posterior fossa subdural hematoma (PFSDH) is a serious and rare condition in newborns, generally occurring after difficult deliveries. But with appropriate treatment, there's an excellent chance of good long-term outcomes ...
21 minutes ago | not rated yet | 0
National guidelines recommend that at-risk women be screened for elevated cholesterol levels to reduce their chances of developing cardiovascular disease. But who is 'at risk?' The results of a study by investigators ...
30 minutes ago | not rated yet | 0
A new study conducted by researchers at the Child Study Center at NYU Langone Medical Center found men diagnosed as children with attention-deficit/hyperactivity disorder (ADHD) were twice as likely to be obese in a 33-year ...
1 hour ago | not rated yet | 0 |