Low-dose CT noninferior for diagnosing appendicitis
(HealthDay) -- For young adults with suspected appendicitis, low-dose computed tomography (CT) is noninferior to standard-dose CT with respect to negative appendectomy rates, according to a study published in the April 26 issue of the New England Journal of Medicine.
Kyuseok Kim, M.D., from the Seoul National University College of Medicine in South Korea, and colleagues conducted a single-blind noninferiority trial for 891 patients with suspected appendicitis, aged 15 to 44 years. Participants were randomly allocated to low-dose CT (444 patients; median radiation dose, 116 mGy/cm) or standard-dose CT (447 patients; median radiation dose, 521 mGy/cm). The rate of negative appendectomies was measured, with a noninferiority margin of 5.5 percent.
The researchers found that the negative appendectomy rate was 3.5 and 3.2 percent in the low-dose and standard-dose CT groups, respectively (difference, 0.3 percent). There were no significant between-group differences in the appendiceal perforation rate (26.5 percent for low-dose CT versus 23.3 percent for standard-dose CT; P = 0.46) or in the proportion of patients who required additional imaging (3.2 and 1.6 percent, respectively; P = 0.09).
"We found that the use of low-dose CT as the first-line imaging test was noninferior to standard-dose CT with respect to the negative appendectomy rate among young adults with suspected appendicitis," the authors write.
The study was supported by a grant from GE Healthcare Medical Diagnostics, Korea.
More information: Full Text (subscription or payment may be required)
Journal reference: New England Journal of Medicine
Copyright © 2012 HealthDay. All rights reserved.
- Low-dose CT method, delivering 50 percent less radiation, correctly identifies patients with appendicitis Jul 22, 2009 | not rated yet | 0
- Simple reduction technique decreases radiation dose associated with CT scans of the head May 06, 2010 | not rated yet | 0
- Preoperative CT useful for younger women with suspected appendicitis Jan 26, 2010 | not rated yet | 0
- ASIR technique significantly reduces radiation dose associated with abdominal CT scans Aug 20, 2010 | not rated yet | 0
- Image filters improve image quality and lower patient radiation dose associated with CT scans May 03, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
(AP)—Government health officials are investigating several health problems reported with potentially contaminated medications made by a Tennessee specialty pharmacy.
Diseases, Conditions, Syndromes 18 hours ago | not rated yet | 0
(HealthDay)—Comorbid conditions often accompany alopecia areata, according to a study published online May 22 in JAMA Dermatology.
Diseases, Conditions, Syndromes 19 hours ago | not rated yet | 0
(HealthDay)—As a world-class golfer, Stacy Lewis' accomplishments are remarkable. But it was a physical challenge in her childhood that defined her ascent to the top of her sport.
Diseases, Conditions, Syndromes 20 hours ago | not rated yet | 0
Saudi Arabia said Friday it would send samples taken from animals possibly infected with a deadly SARS-like virus to the United States for testing in a bid to find the source of disease.
Diseases, Conditions, Syndromes 23 hours ago | not rated yet | 0
The World Health Organization voiced deep concern Thursday over the SARS-like virus that has killed 22 people in less than a year, saying it might potentially spread more widely between humans.
Diseases, Conditions, Syndromes May 24, 2013 | 5 / 5 (1) | 0
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
2 hours ago | not rated yet | 4
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
2 hours ago | not rated yet | 1
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
1 hour ago | not rated yet | 0
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
2 hours ago | not rated yet | 0
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
23 hours ago | 5 / 5 (3) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
20 hours ago | 3.7 / 5 (3) | 2 |