Metabolites linked to insulin resistance in normoglycemia

April 23, 2012
Metabolites linked to insulin resistance in normoglycemia

(HealthDay) -- Twenty metabolites, including amino acids, intermediates in glucose synthesis, ketone bodies, and fatty acids, are associated with insulin resistance, according to a study published online April 17 in Diabetes.

Peter Würtz, Ph.D., from the University of Oulu in Finland, and colleagues performed metabolic profiling using high-throughput nuclear magnetic resonance spectroscopy in 7,098 Finns (mean age, 31 years; 52 percent women).

The researchers identified 20 metabolites that were significantly associated with the homeostasis model assessment of (HOMA-IR). These included branched-chain and aromatic amino acids, intermediates in gluconeogenesis, ketone bodies, and fatty acid composition and saturation. Associations for amino acids Leu, Ile, Val, and Tyr were sex- and obesity-dependent, with significant associations only seen in abdominally obese women. Protein energy intake was associated with some (Val, Phe, Tyr, and Gln) but not with the insulin resistance index. One of 12 genetic determinants of HOMA-IR, a variant in GCKR, was significantly associated with 12 .

"Metabolic signatures extending beyond obesity and lipid abnormalities reflected the degree of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints," Würtz and colleagues conclude.

Explore further: Trans-fatty acids and insulin sensitivity

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Trans-fatty acids and insulin sensitivity

July 8, 2008

Trans-fatty acids have been the topic of a lot of negative health news, but in the July Journal of Lipid research, a dietary study in rats suggests that trans-fats do not increase the risk of insulin resistance and diabetes, ...

Insulin resistance increases risk of colorectal adenomas

March 27, 2012

(HealthDay) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according to a study published ...

Recommended for you

Diets avoiding dry-cooked foods can protect against diabetes

August 24, 2016

Simple changes in how we cook could go a long way towards preventing diabetes, say researchers at the Icahn School of Medicine at Mount Sinai. A new randomized controlled trial, published online July 29 in the journal Diabetologia, ...

New study reveals a novel protein linked to type 2 diabetes

August 16, 2016

Findings from Boston University School of Medicine (BUSM), which appear in eLife, provide a possible explanation as to why most people who are obese develop insulin resistance and type 2 diabetes. A minority of obese individuals, ...

Bacteria may cause type 2 diabetes

June 1, 2015

Bacteria and viruses have an obvious role in causing infectious diseases, but microbes have also been identified as the surprising cause of other illnesses, including cervical cancer (Human papilloma virus) and stomach ulcers ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.