Metabolites linked to insulin resistance in normoglycemia

Metabolites linked to insulin resistance in normoglycemia

(HealthDay) -- Twenty metabolites, including amino acids, intermediates in glucose synthesis, ketone bodies, and fatty acids, are associated with insulin resistance, according to a study published online April 17 in Diabetes.

Peter Würtz, Ph.D., from the University of Oulu in Finland, and colleagues performed metabolic profiling using high-throughput nuclear magnetic resonance spectroscopy in 7,098 Finns (mean age, 31 years; 52 percent women).

The researchers identified 20 metabolites that were significantly associated with the homeostasis model assessment of (HOMA-IR). These included branched-chain and aromatic amino acids, intermediates in gluconeogenesis, ketone bodies, and fatty acid composition and saturation. Associations for amino acids Leu, Ile, Val, and Tyr were sex- and obesity-dependent, with significant associations only seen in abdominally obese women. Protein energy intake was associated with some (Val, Phe, Tyr, and Gln) but not with the insulin resistance index. One of 12 genetic determinants of HOMA-IR, a variant in GCKR, was significantly associated with 12 .

"Metabolic signatures extending beyond obesity and lipid abnormalities reflected the degree of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints," Würtz and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Insulin resistance increases risk of colorectal adenomas

Mar 27, 2012

(HealthDay) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according ...

Recommended for you

Magnesium cuts diabetes risk

6 hours ago

Getting enough magnesium in the diet may reduce the risk of diabetes, especially for those who already show signs of heading that way.

Personalised treatment for stress-related diabetes

Oct 14, 2014

Researchers at Lund University in Sweden are testing a treatment for type 2 diabetes which targets the disease mechanism itself - and not just the symptoms. For the first time, knowledge about the individual patient's genetic ...

Sensors to simplify diabetes management

Oct 13, 2014

For many patients diagnosed with diabetes, treating the disease can mean a burdensome and uncomfortable lifelong routine of monitoring blood sugar levels and injecting the insulin that their bodies don't ...

Androgen receptor signaling tied to insulin resistance

Oct 09, 2014

(HealthDay)—Mouse models show tissue-specific androgen receptor (AR) signaling is involved in regulation of metabolism, which may explain the link between androgen deprivation therapy (ADT) and the development ...

User comments