Pattern of disc degeneration impacts low back pain

Pattern of disc degeneration impacts low back pain

(HealthDay) -- Contiguous, multilevel disc degeneration (CMDD) is associated with increased likelihood of low back pain (LBP) and pain severity compared with skipped level disc degeneration (SLDD), according to a study published in the April 1 issue of Spine.

To investigate the clinical relevance of SLDD compared with that of CMDD of the lumbar spine, Kenneth M.C. Cheung, M.D., M.B.B.S., of the University of Hong Kong, and colleagues conducted a cross-sectional radiographic and clinical evaluation of 3,099 Chinese patients. A total of 1,457 patients with multilevel of the lumbar spine on T2-weighted were stratified into SLDD (301 patients) or CMDD (1,156 patients). Based on the relative location of nondegenerated normal discs to degenerated disc levels, SLDD was further classified into five types from I (least severe) to V (most severe).

The researchers found that, compared with SLDD, CMDD was associated with an increased likelihood of historical LBP (odds ratio [OR], 1.39) and (OR, 1.83). Increasing severity of SLDD type correlated with a significant increasing trend of number of levels of disc degeneration, disc degeneration severity, and presence of disc bulges/extrusions. In SLDD type V there was a higher prevalence of LBP and higher . There was no difference in scores between CMDD and SLDD or within SLDD types.

"Our study suggests that subjects with a similar degree but different patterns of multilevel disc degeneration do differ with respect to low back symptoms," the authors write. "This finding may provide new evidence with regard to the mechanism of LBP."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Exercise produces positive effects on the intervertebral discs

date Jun 28, 2011

Physical exercise has a positive effect on the formation of cells in the intervertebral discs. This is shown by a study from the Sahlgrenska Academy, University of Gothenburg, presented at the annual meeting of the International ...

Researcher tags genes linked to disc degeneration

date Mar 11, 2009

(PhysOrg.com) -- Lumbar disc degeneration is an uncomfortable condition that affects millions of people, but two University of Alberta researchers have identified some of the genes that are causing problems. ...

Recommended for you

Bacteria blamed in indigenous Mexican baby deaths

date 20 hours ago

Bacteria—and not a contaminated vaccine as initially suspected—were to blame for the recent deaths of two Mexican babies and for sickening 29 others, according to an official investigation.

Explainer: What is Chagas disease?

date May 22, 2015

According to an article in the Journal of the American Medical Association (JAMA), in a Los Angeles clinic treating patients with heart failure, about 20% of Latin American patients have Chagas disease. What is that?, y ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.