Pattern of disc degeneration impacts low back pain

April 12, 2012
Pattern of disc degeneration impacts low back pain

(HealthDay) -- Contiguous, multilevel disc degeneration (CMDD) is associated with increased likelihood of low back pain (LBP) and pain severity compared with skipped level disc degeneration (SLDD), according to a study published in the April 1 issue of Spine.

To investigate the clinical relevance of SLDD compared with that of CMDD of the lumbar spine, Kenneth M.C. Cheung, M.D., M.B.B.S., of the University of Hong Kong, and colleagues conducted a cross-sectional radiographic and clinical evaluation of 3,099 Chinese patients. A total of 1,457 patients with multilevel of the lumbar spine on T2-weighted were stratified into SLDD (301 patients) or CMDD (1,156 patients). Based on the relative location of nondegenerated normal discs to degenerated disc levels, SLDD was further classified into five types from I (least severe) to V (most severe).

The researchers found that, compared with SLDD, CMDD was associated with an increased likelihood of historical LBP (odds ratio [OR], 1.39) and (OR, 1.83). Increasing severity of SLDD type correlated with a significant increasing trend of number of levels of disc degeneration, disc degeneration severity, and presence of disc bulges/extrusions. In SLDD type V there was a higher prevalence of LBP and higher . There was no difference in scores between CMDD and SLDD or within SLDD types.

"Our study suggests that subjects with a similar degree but different patterns of multilevel disc degeneration do differ with respect to low back symptoms," the authors write. "This finding may provide new evidence with regard to the mechanism of LBP."

Explore further: Exercise produces positive effects on the intervertebral discs

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Exercise produces positive effects on the intervertebral discs

June 28, 2011

Physical exercise has a positive effect on the formation of cells in the intervertebral discs. This is shown by a study from the Sahlgrenska Academy, University of Gothenburg, presented at the annual meeting of the International ...

Recommended for you

The 'love hormone' may quiet tinnitus

September 23, 2016

(HealthDay)—People suffering from chronic ringing in the ears—called tinnitus—may find some relief by spraying the hormone oxytocin in their nose, a small initial study by Brazilian researchers suggests.

Bile acid uptake inhibitor prevents NASH / fatty liver in mice

September 21, 2016

Drugs that interfere with bile acid recycling can prevent several aspects of NASH (nonalcoholic steatohepatitis) in mice fed a high-fat diet, scientists from Emory University School of Medicine and Children's Healthcare of ...

New therapeutic target for Crohn's disease

September 20, 2016

Research from the Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a promising new target for future drugs to treat inflammatory bowel disease (IBD). The study, published today in Cell Reports, also indicates ...

Arthritis drug may help with type of hair loss

September 22, 2016

(HealthDay)—For people who suffer from a condition that causes disfiguring hair loss, a drug used for rheumatoid arthritis might regrow their hair, a new, small study suggests.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.