Scientists find neural stem cell regulator
Researchers at the University of Colorado School of Medicine have found that lack of a specific gene interrupts neural tube closure, a condition that can cause death or paralysis.
"The neural tube is the beginning of the brain and spinal cord," said the study's lead investigator Lee Niswander, Ph.D., professor of pediatrics at the CU School of Medicine. "A defect in the mLin41 gene doesn't allow the tube to close because not enough neural progenitor cells are being made. The study was the cover story this week in the journal Genes & Development.
Niswander and the paper's first author, Jianfu Chen, Ph.D., made their findings while studying neural stem cells in mice. They said the cells use distinct self-renewal programs to meet the demand of tissue growth and repair during different stages of embryonic development. The molecular mechanisms that control these programs remain largely unknown.
The researchers discovered that the gene mLin41 in mice controls the extent of neural stem cell proliferation during the process of neural closure but not at the later stage of brain development.
According to Chen, mLin41 works with small RNAs and RNA regulators that have never been investigated before in connection with neural tube formation.
Niswander, who is also an investigator with the Howard Hughes Medical Institute based in Washington, D.C., said the findings shed new light on neural tube development.
"Our work opens up a whole other pathway toward understanding neural tube defects," she said. "It's a new and significant piece of the puzzle behind understanding how this happens."
Provided by University of Colorado Denver
- New findings may shed light on brain and spinal cord birth defects Jan 19, 2010 | not rated yet | 0
- Mouse experiments show fickle functions for folic acid Oct 06, 2011 | not rated yet | 0
- One step closer to closure: Neuroscientists discovery key to spinal cord defects Dec 28, 2009 | not rated yet | 0
- Study: Neural stem cells are long-lived Oct 05, 2005 | not rated yet | 0
- Some neural tube defects in mice linked to enzyme deficiency May 25, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
Genetics 1 hour ago | not rated yet | 0 |
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Genetics May 20, 2013 | 5 / 5 (1) | 0 |
Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.
Genetics May 16, 2013 | 3 / 5 (1) | 1 |
Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begins to use the tools of ...
Genetics May 16, 2013 | 5 / 5 (1) | 3 |
Ethicists provide framework supporting new recommendations on reporting incidental findings in gene sequencing
In a paper published in Science Express, a group of experts led by bioethicists in the Center for Medical Ethics and Health Policy at Baylor College of Medicine provide a framework for the new American College of Medical Geneti ...
Genetics May 16, 2013 | not rated yet | 0
In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe ...
28 minutes ago | not rated yet | 0 |
Researchers have developed a new drug delivery system that allows inhalation of chemotherapeutic drugs to help treat lung cancer, and in laboratory and animal tests it appears to reduce the systemic damage ...
39 minutes ago | not rated yet | 0 |
Moving objects attract greater attention – a fact exploited by video screens in public spaces and animated advertising banners on the Internet. For most animal species, moving objects also play a major ...
43 minutes ago | not rated yet | 0 |
In the long run, encouraging a baby to finish the last ounce in their bottle might be doing more harm than good.
41 minutes ago | not rated yet | 0 |
When turned on, the gene p53 turns off cancer. However, when existing drugs boost p53, only a few tumors die – the rest resist the challenge. A study published in the journal Cell Reports shows how: tumors that live even i ...
42 minutes ago | not rated yet | 0 |
Children living in households where the parents are married are less likely to be obese, according to new research from Rice University and the University of Houston.
36 minutes ago | not rated yet | 0