Researchers uncover multiple faces of deadly breast cancer
An international team of scientists, including four at Simon Fraser University, has made a discovery that will change the way the most deadly form of breast cancer is treated.
The journal Nature has just published the team's findings online in the paper The clonal and mutational evolution spectrum of primary triple negative breast cancers.
The study is the largest genetic analysis of what were thought to be triple negative breast cancer tumours.
The 59 scientists involved in this study expected to see similar gene profiles when they mapped on computer the genomes of 100 tumours.
But to their amazement they found no two genomes were similar, never mind the same. "Seeing these tumours at a molecular level has taught us we're dealing with a continuum of different types of breast cancer here, not just one," explains Steven Jones, co-author of this study.
The SFU molecular biology and biochemistry professor, who heads up bioinformatics research at the BC Cancer Agency, adds: "The genetic diversity of these tumours, even though they're clinically similar, probably explains why they are so difficult to treat. These findings prove the importance of personalizing cancer drug treatment so that it targets the genetic make up of a particular tumour rather than presuming one therapy can treat multiple, similar-looking tumours."
Triple negative breast cancer lacks surface cell receptors for estrogen, progesterone and herceptin a hormone, steroid and protein, respectively, linked to breast cancer. It strikes 16 per cent of women who develop breast cancer and targets mainly those under age 40.
Scientists consider it the most deadly form of breast cancer because it doesn't respond well to modern drug therapies, which knock out receptors found in most breast cancers but not this one.
Typically, triple negative breast cancer patients need everything thrown at them surgery, chemotherapy and radiation to have any hope of going into remission.
Jones credits the affordability of genetic sequencing a process that now takes tens of thousands rather than millions of dollars to do with making tumour analysis at the molecular level more readily available.
More information: DOI: 10.1038/nature10933
Provided by Simon Fraser University
- Five-year U.K. breast cancer trial starts Jan 16, 2008 | not rated yet | 0
- Silencing a deadly conversation in breast cancer Jun 02, 2011 | not rated yet | 0
- Risk of aggressive breast cancer subtype three times higher for black women Mar 25, 2009 | not rated yet | 0
- Breaking the backbone of triple-negative breast cancers Mar 19, 2012 | not rated yet | 0
- Some breast cancer tumors may be resistant to a common chemotherapy treatment Mar 27, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in ...
Cancer 10 hours ago | not rated yet | 0
Research presented at Digestive Disease Week (DDW) explores new methods for managing digestive health through diet and lifestyle.
Cancer 10 hours ago | not rated yet | 1
A ground-breaking advance in colonoscopy technology signals the future of colorectal care, according to research presented today at Digestive Disease Week(DDW). Additional research focuses on optimizing the minimal withdrawal ...
Cancer May 18, 2013 | 5 / 5 (2) | 0
(HealthDay)—Concurrent use of two immune checkpoint antibodies—ipilimumab and nivolumab—may be effective for the treatment of advanced melanoma, according to a proof-of-principal study presented in ...
Cancer May 17, 2013 | not rated yet | 0
(HealthDay)—The risks of metastasis and death associated with cutaneous squamous cell carcinoma (CSCC) are low, but significant, and risk factors for poor outcome include tumor diameter, invasion beyond ...
Cancer May 17, 2013 | not rated yet | 0 |
The devastating effect of Alzheimer's disease on bilingual people has been thrown into focus in Canada, where the sudden loss of a second language can leave sufferers feeling like strangers in their own country.
1 hour ago | not rated yet | 0
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
3 hours ago | not rated yet | 0
Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease ...
11 hours ago | not rated yet | 0 |
Patients with treatment-resistant major depression saw dramatic improvement in their illness after treatment with ketamine, an anesthetic, according to the largest ketamine clinical trial to-date led by researchers from the ...
11 hours ago | 4.7 / 5 (3) | 0 |
There are significant cost and risk factors associated with two procedures commonly used to diagnose or treat gastrointestinal problems, according to research presented at Digestive Disease Week (DDW).
10 hours ago | not rated yet | 0