Amino acid levels linked to type 2 diabetes risk

Amino acid levels linked to type 2 diabetes risk

(HealthDay) -- Levels of some amino acids are associated with glycemia and insulin resistance and predict the development of type 2 diabetes in men, according to a study published online May 2 in Diabetes.

Alena Stancakova, M.D., Ph.D., from the University of Eastern Finland in Kuopio, and colleagues examined the association between glycemia, 43 single associated with hyperglycemia or type 2 diabetes, and levels of eight amino acids in 9,369 Finnish men either without diabetes or with newly-diagnosed type 2 diabetes.

After 4.7 years, the researchers found that alanine, leucine, isoleucine, tyrosine, and glutamine levels predicted incident type 2 diabetes, which was largely mediated by with the exception of glutamine. Increased glycemia (increased fasting and two hour ) was associated with higher levels of branched-chain, aromatic amino acids and alanine and lower levels of histidine and glutamine. was associated with expression of genes regulating amino acid degradation in adipose tissue. One risk allele, a variant of GCKR, was significantly correlated with lower levels of alanine and isoleucine and higher levels of glutamine.

"In conclusion, the levels of branched-chain, aromatic amino acids and alanine increased and the levels of glutamine and histidine decreased with increasing glycemia, reflecting, at least in part, insulin resistance," Stancakova and colleagues write. "Only one single nucleotide polymorphism regulating hyperglycemia was significantly associated with amino acid levels."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Metabolites linked to insulin resistance in normoglycemia

Apr 23, 2012

(HealthDay) -- Twenty metabolites, including amino acids, intermediates in glucose synthesis, ketone bodies, and fatty acids, are associated with insulin resistance, according to a study published online April ...

Recommended for you

Blood glucose levels set for achieving HbA1c targets

Apr 11, 2014

(HealthDay)—The average self-monitored blood glucose (SMBG) concentrations needed at premeal, postmeal, and bedtime have been established to achieve a range of hemoglobin A1c (HbA1c) targets, according ...

Women with diabetes less likely to have a mammogram

Apr 11, 2014

Women with diabetes are 14 per cent less likely to be screened for breast cancer compared to women without diabetes, according to a study by researchers at the Institute for Clinical Evaluative Sciences (ICES) and Women's ...

Nonalcoholic fatty liver disease linked to CKD in T1DM

Apr 09, 2014

(HealthDay)—For patients with type 1 diabetes, nonalcoholic fatty liver disease (NAFLD) is independently associated with the risk of incident chronic kidney disease (CKD), according to a study published ...

Common diabetes treatment could extend hypoglycaemia

Apr 08, 2014

(Medical Xpress)—Researchers at the University of Adelaide have discovered that a common treatment for people with type 2 diabetes could cause longer-than-normal periods of the low blood sugar reaction hypoglycaemia, which ...

User comments