Anti-HIV drug tenofovir is safe to take during pregnancy
Pre-birth exposure to the anti-HIV drug tenofovir does not adversely affect pregnancy outcomes and does not increase birth defects, growth abnormalities, or kidney problems in infants born to African women who are HIV positive, supporting the use of this drug during pregnancy, according to a study by a team of international researchers published in this week's PLoS Medicine.
The researchers led by Diana Gibb from the MRC Clinical Trials Unit in London, UK, analyzed data collected on pregnancy and infant outcomes among Ugandan and Zimbabwean HIV-positive women who took Antiretroviral therapy (ART - a combination of anti-HIV drugs) during pregnancy in the Development of AntiRetroviral Therapy in Africa (DART) trial. DART was a large randomised controlled trial that compared different approaches for monitoring anti-retroviral therapy in over 3000 adults. As part of the trial, researchers collected data on any pregnancies among women taking part, including drugs they received; babies were followed for up to 4 years.
Most of the women who became pregnant were taking a tenofovir-containing combination of anti-HIV drugs before and throughout their pregnancies and out of the 226 live births, the researchers recorded that there was no increase in the proportion of infants who died soon after birth (3%) or had birth defects (also 3%), comparing those exposed and not exposed to tenofovir-containing anti-retroviral therapy during pregnancy.
Of 182 surviving infants enrolled in a follow-up study, 14 subsequently died giving a 1-year mortality rate of 5%, similar to the 2% infant mortality normally seen in the region, and much lower than among babies born to severely HIV infected untreated mothers. Furthermore, the researchers found that none of the surviving infants who were tested for HIV were positive and no bone fractures or kidney problems occurred during follow-up and there was no effect on growth at 2 years.
The researchers say: "we observed no evidence that tenofovir versus non-tenofovir ART had any adverse effects on pregnancy outcomes or on congenital, renal, bone, or growth abnormalities up to age 4 y among children born to women with severe HIV immunodeficiency at ART initiation and exposed throughout the intrauterine period."
They continue: "Our findings suggest tenofovir-containing ART is a reasonable choice in pregnancy and that tenofovir pre-exposure prophylaxis is also reasonable for women who are at high risk of seroconverting during pregnancy."
The researchers add: "Detailed safety of tenofovir for pre-exposure prophylaxis will need confirmation from longer term follow-up of larger numbers of exposed children."
More information: Gibb DM, Kizito H, Russell EC, Chidziva E, Zalwango E, et al. (2012) Pregnancy and Infant Outcomes among HIV-Infected Women Taking Long-Term ART with and without Tenofovir in the DART Trial. PLoS Med 9(5): e1001217. doi:10.1371/journal.pmed.1001217
Journal reference: PLoS Medicine
Provided by Public Library of Science
- Anti-HIV drug use during pregnancy does not affect infant size, birth weight May 02, 2012 | not rated yet | 0
- Anti-HIV gel being evaluated in pregnant and breastfeeding women Jun 20, 2011 | not rated yet | 0
- Oral pill trial to halt HIV in women is stopped Apr 19, 2011 | not rated yet | 0
- NIH modifies 'VOICE' HIV prevention study in women Sep 28, 2011 | not rated yet | 0
- Antiretroviral drugs may protect against sexual transmission of HIV Feb 05, 2008 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
(HealthDay)—For HIV-infected individuals with recurrent Clostridium difficile infection, fecal microbiota therapy is feasible, according to a letter published in the May 21 issue of the Annals of Intern ...
HIV & AIDS 1 hour ago | not rated yet | 0
Canadian health authorities lifted Wednesday what was effectively a ban on gay men giving blood, announcing new rules making men who have not had sex with men in the past five years eligible.
HIV & AIDS 3 hours ago | not rated yet | 0
Top AIDS scientists were optimistic Wednesday of finding a cure for the disease that has claimed 30 million lives—but said it might not work for all people.
HIV & AIDS 6 hours ago | not rated yet | 0
The integration of mental health interventions into HIV prevention and treatment platforms can reduce the opportunity costs of care and improve treatment outcomes, argues a new Policy Forum article published in this week's ...
HIV & AIDS May 21, 2013 | not rated yet | 0
Calorie information in fast food restaurants used by 40 percent of 9-18 year olds when making food choices
A new study published online today (Thursday) in the Journal of Public Health has found that of young people who visited fast food or chain restaurants in the U.S. in 2010, girls and youth who were obese were more likely ...
31 minutes ago | not rated yet | 0
(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.
3 hours ago | 5 / 5 (1) | 0 |
Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.
6 hours ago | 4.5 / 5 (2) | 0 |
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
3 hours ago | not rated yet | 2 |
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
6 hours ago | not rated yet | 0 |
An independent panel of experts on Wednesday recommended US approval of a new Merck sleeping pill called suvorexant, but expressed concerns over the highest dosage and risks of drowsy daytime driving.
1 hour ago | not rated yet | 0