Automated insulin dosage titration system demonstrates positive clinical study results
Newly published results from a clinical study of the Diabetes Insulin Guidance System (DIGS), under development by Hygieia, Inc., demonstrate DIGS' potential to improve blood glucose control for insulin-using patients with type 2 or type 1 diabetes. DIGS automatically adjusted insulin dosage based on each individual's reported blood glucose results. Over the 12-week intervention period of the study, investigators observed:
- Out of a total of 1,734 individual dosage adjustments, the study team over-rode the DIGS-instructed dosage only twice.
- Mean HbA1c levels decreased from a baseline of 8.4%(±0.8) to 7.9%(±0.9); (p<0.05);
- Average patient blood glucose levels improved progressively from a baseline of 174.2 mg/dL(±36.7) to 163.3mg/dL(±35.1); (p<0.03); and
- Glucose levels falling below the hypoglycemic threshold (glucose < 65 mg/dL) during the 12-week active phase were significantly milder than the ones reported during the 4-week run-in period (P = 0.02).
Ultimately, most patients with type 2 diabetes and all patients with type 1 diabetes require insulin therapy. However, despite the availability of a variety of insulin formulations and treatment regimens, most insulin users do not achieve an optimal glycemic target (e.g. HbA1c<7%) and are thus at increased risk of developing complications of diabetes. Over the years, multiple clinical studies have shown that frequent insulin dosage titration is a key element for achieving and maintaining good glycemic control, with physicians or other diabetes experts contacting patients every few days or weeks to make dosage adjustments. Unfortunately, implementation of such frequent insulin titration in day-to-day clinical practice has been hindered by a lack of sufficient medical expertise as well as limited time for frequent health care provider contact.
"The proprietary DIGS technology developed by Hygieia, Inc. measures blood glucose, analyzes patterns in those measurements, and automates insulin dosage titration," said Dr. Bergenstal. "In this study, our team found that DIGS worked amazingly well. After a four-week run-in to establish baseline glucose levels for each patient, 1734 individual insulin dosage adjustments were made by the DIGS software over the 12 week intervention period. Our team gave those newly determined insulin dosage instructions to the study participants each week without changing the suggested intervention in all but two instances. This demonstrates the possibility that DIGS could automate weekly dosage adjustment safely and effectively something that none of our current tools is capable of achieving."
Mary Johnson, Director of Research at the International Diabetes Center, stated regarding results achieved by one of the study participants, "We accomplished in 12 weeks using DIGS what our usual standard of care might have taken three years to do."
Asked what DIGS in a handheld device might afford those on insulin therapy, Martha Funnell, MS, RN, CDE, Research Scientist, Michigan Diabetes Research and Training Center, University of Michigan remarked, "This technology might just enable us to provide many more patients with the ability to achieve our best standards of care. The benefits could go beyond better glycemic control and help people with diabetes feel more confident about managing their insulin between health care appointments."
Provided by Kureczka/Martin Associates
- Patients with Type 2 diabetes may not benefit from oral medication as well as insulin Apr 20, 2012 | not rated yet | 0
- Artificial pancreas may improve overnight control of diabetes in adults Apr 15, 2011 | not rated yet | 0
- Bypassing the insulin highway Apr 28, 2008 | not rated yet | 0
- Intermittent exercise improves blood glucose control for diabetics Feb 02, 2012 | not rated yet | 0
- New diabetes treatment lowers blood sugar with less need for insulin Feb 16, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
gravity is std. therefore can we rate a 'mass at height' by watts?
3 hours ago For example.... wind turbines are primarily listed by their wattage (1.5MW etc.) Presumably their output is varied according to rotational speed, so...
Calculating on-axis elements of a solenoid
15 hours ago I wanted to mention that this solenoid has many winds over many layers. The thickness of the windings is 2.4 inches coming off of the engineering...
latitude & longitude & air pressure
17 hours ago Hi there, I have a peculiar question. Imagine that you are in a earth position, obtained by google, that gives you the latitude and longitude....
Differences of Classical Mechanics when learned with Calc vs algebra?
20 hours ago what are the differences? Every example I find usually has a derivative or integral or some kind of calculus defined concept that seems to make it...
what is the distance traveled
May 22, 2013 A rough sketch of experiment. Image: http://i43.tinypic.com/14t4sk5.png the red dots represent a side view of path traveled, F is downward force...
Image of a Convex Lens Cut in Half Horizontally
May 22, 2013 Hello everyone, A friend of mine came up with this question in class and I really do not have a good answer. Suppose you have a convex lens...
- More from Physics Forums - Classical Physics
More news stories
Widely-used fish oil supplements modestly increase amounts of a hormone that is associated with lower risk of diabetes and heart disease, according to a study accepted for publication in The Endocrine Society's Journal of ...
Diabetes 23 hours ago | 5 / 5 (1) | 0
Study shows that women who smoke during pregnancy increase the risk of both obesity and gestational diabetes in their da
Women who smoke during pregnancy increase the risk of both obesity and gestational diabetes, in their daughters, concludes research published in Diabetologia, the journal of the European Association for the Study of Diabet ...
Diabetes May 20, 2013 | not rated yet | 0
The number of young people diagnosed with type 2 diabetes has seen the sharpest rise over the last twenty years compared to a background of a general increase across the board, new University research has ...
Diabetes May 20, 2013 | not rated yet | 1
(Medical Xpress)—Flinders University researchers are breaking new ground in a decade-long journey to pinpoint the function of two closely related proteins.
Diabetes May 20, 2013 | 5 / 5 (2) | 0 |
(HealthDay)—Moderate aerobic exercise prevents fructose-induced hypertriglyceridemia in healthy males, according to a study published online May 14 in Diabetes.
Diabetes May 17, 2013 | 5 / 5 (1) | 0 |
A new coronavirus has now claimed 22 lives worldwide out of 44 lab-confirmed cases, mostly in Saudi Arabia, World Health Organization officials said Thursday.
1 hour ago | not rated yet | 0
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
1 hour ago | 4.7 / 5 (3) | 0 |
Gaucher disease causes debilitating and sometimes fatal neurodegeneration in early childhood. Recent studies have uncovered a link between the mutations responsible for Gaucher disease and an increased risk ...
1 hour ago | not rated yet | 0 |
Scientists have uncovered a survival mechanism that occurs in breast cells that have just turned premalignant-cells on the cusp between normalcy and cancers-which may lead to new methods of stopping tumors.
1 hour ago | not rated yet | 0 |
As the human body fine-tunes its neurological wiring, nerve cells often must fix a faulty connection by amputating an axon—the "business end" of the neuron that sends electrical impulses to tissues or other ...
1 hour ago | 5 / 5 (1) | 0 |
A study by researchers at Henry Ford Hospital found "substantial evidence" that a regenerative process involving damaged nerve fibers in the spinal cord could hold the key to better functional recovery by most stroke victims.
1 hour ago | not rated yet | 0 |