Body clock genes unravelled
International travellers, shift workers and even people suffering from obesity-related conditions stand to benefit from a key discovery about the functioning of the body's internal clock.
Professor Chris Liddle, from the Westmead Millennium Institute for Medical Research, the University of Sydney, worked with a team from the Salk Institute based in California, to demonstrate the importance of circadian receptors found in the brain and the liver. Their findings are published in Nature .
"The research is important as these are the first core component of the circadian clock identified that can be targeted with drugs, which could provide relief for those affected by disrupted circadian rhythms," said Professor Liddle.
"Previously we have known that there are body 'clocks' not only in the brain but in most other body tissues including the liver, part of the focus of this study. While the brain clock is mainly cued by light, these other clocks are cued by factors such as exercise and diet as well as receiving nerve and hormone signals from the central clock in the brain."
People with circadian disturbances tend to have a higher incidence of health concerns such as obesity, diabetes and related metabolic disorders. It is much more than simply a problem of disturbed sleep.
"People tend to think that the clock is just something that happens in the brain but it's a whole-body issue. Literally you do not feel like exercising and your metabolism slows when you are in a certain part of the cycle. This contributes to obesity-related problems.
"When you fly overseas, not only do you wake up in the middle of the night, you probably notice you want to eat in the middle of the night, and that during the day you have reduced energy. The liver is a key player in the regulation of energy and we now understand quite a bit more how liver genes 'clock in' to the circadian cycle."
Professor Liddle, a liver expert who has worked on liver genes for more than a decade with the Salk Institute, said the team had been able to show that these receptors in the liver were important in controlling the metabolism of fats and other genes related to diet, nutrition, digestion and energy expenditure.
"This is a very exciting discovery. We have now shown that these receptors in the body's tissues do not have a peripheral role but are core components for setting our body clock that we can potentially use drugs on.
"The promise of this research for the future is that we can specifically target drug treatments at these receptors. The hope is that not only problems like jet lag and disturbed sleep can be more easily managed but other associated health concerns can be addressed more effectively," Professor Liddle said.
More information: Nature 485, 123127 (03 May 2012) doi:10.1038/nature11048
Journal reference: Nature
Provided by University of Sydney
- Scientists redraw the blueprint of the body's biological clock Apr 06, 2012 | not rated yet | 0
- Failure of brain's clock could play role in causing neuropsychiatric disorders Sep 21, 2011 | not rated yet | 0
- 'Wrong'-time eating reduces fertility in fruit flies Jun 07, 2011 | not rated yet | 0
- Coordinating the circadian clock: Researchers find that molecular pair controls time-keeping and fat metabolism Apr 04, 2012 | not rated yet | 0
- Scientists find high-fat diet disrupts body clock Nov 06, 2007 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
Genetics 4 hours ago | 5 / 5 (1) | 0 |
Can human genes be patented? That was the question posed by Alan J. Snyder, vice president and associate provost for research and graduate studies at Lehigh, and Lee Kaplan, scientific director of cellular and molecular genetics ...
Genetics 11 hours ago | 4 / 5 (1) | 0
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
Genetics May 22, 2013 | 4.5 / 5 (4) | 0 |
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Genetics May 20, 2013 | 5 / 5 (1) | 0 |
Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.
Genetics May 16, 2013 | 3 / 5 (1) | 1 |
(Medical Xpress)—A new study by researchers in the US has shown that an ancient virus can be modified to help in the fight against the simian immunodeficiency virus SIV, which is the equivalent in monkeys ...
10 hours ago | 5 / 5 (3) | 0 |
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
7 hours ago | 5 / 5 (1) | 0 |
Talking on a hands-free device while behind the wheel can lead to a sharp increase in errors that could imperil other drivers on the road, according to new research from the University of Alberta.
3 hours ago | not rated yet | 0
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
7 hours ago | 5 / 5 (2) | 0 |
Kate O'Reilly's spring allergy survival kit includes the usual stuff - nasal sprays, allergy pills and a box of tissues. This season, she's added a new weapon to her line of defense: an app on her smartphone.
5 hours ago | not rated yet | 0