Stopping cell migration may help block fibrosis and the spread of cancer
(Medical Xpress) -- Discoveries by a Yale-led team of scientists could lead the way for development of new therapies for treating fibrosis and tumor metastasis. The researchers have both uncovered a signaling pathway that promotes cell migration in certain forms of pulmonary fibrosis, a deadly lung disease, and developed a drug treatment that may block the cancer cell migration. The study appears in the Advance Online Publication of Nature Cell Biology.
Pulmonary fibrosis is the development of excessive connective tissue in the lungs. It can develop without a known cause, and produces permanent scar tissue in the lungs. There is no known cure or treatment to slow down its progress.
Cell migration is the biological process by which cells move around the body, often contributing to the development or spread of diseases such as fibrosis or metastatic cancer.
Fibroblast connective tissue cells and cancer cells migrate in a way that requires sustained activation of signaling pathways. But until now the regulation of these cellular functions has been poorly understood. The Yale team studied the workings of a stimulant of cell migration known as lysophosphatidic acid (LPA). They identified the chemical reactions that ultimately induce cell migration, but more importantly, discovered a way to block the pathway via inhibition of the proteins responsible for promoting the migration.
Senior author Dianqing (Dan) Wu, professor of pharmacology and vascular biology at Yale School of Medicine and member of Yale Cancer Center, explained, Our ability to block the pathway provides a potential therapeutic target for treating pulmonary fibrosis, a very serious disease that lacks effective treatments, and other types of fibrosis. Because cancer cells, particularly melanoma and lung cancer cells containing activated BRAF genetic mutations, can use this signaling pathway to migrate, blocking this pathway could also prevent metastasis of these cancers.
More information: Other authors are Xiaoqing Gan, Jiyong Wang and Chen Wang of Yale; Eeva Sommer and Dario Alessi of the University of Dundee; Tohru Kozasa of the University of Illinois at Chicago; Srinivasa Srinivasula of the National Cancer Institute; Stefan Offermanns of the Max-Planck-Institute for Heart and Lung Research; and Melvin I. Simon of the University of California at San Diego.
The study was supported by grants from the National Institutes of Health and the Ellison Medical Foundation.
Journal reference: Nature Cell Biology
Provided by Yale University
- Scarred lungs leave trail of beta arrestins Mar 28, 2011 | not rated yet | 0
- Progression of lung fibrosis blocked in mouse model Oct 05, 2011 | not rated yet | 0
- Signaling between protein, growth factor is critical for coordinated cell migration Nov 10, 2008 | not rated yet | 0
- New genetic path for scleroderma: Patient biopsies reveal potential new target for therapy Mar 19, 2012 | not rated yet | 0
- Researchers learn how lung fibrosis begins and could be treated Jun 27, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How can there be a term called "intestinal metaplasia" of stomach
8 hours ago Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
- More from Physics Forums - Medical Sciences
More news stories
Widely available in pharmacies and health stores, phosphatidylserine is a natural food supplement produced from beef, oysters, and soy. Proven to improve cognition and slow memory loss, it's a popular treatment for older ...
Medical research 2 hours ago | 5 / 5 (1) | 0 |
Researchers at Emory University have identified a protein that stimulates a pair of "orphan receptors" found in the brain, solving a long-standing biological puzzle and possibly leading to future treatments for neurological ...
Medical research 3 hours ago | not rated yet | 0 |
Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.
Medical research 3 hours ago | 4.5 / 5 (2) | 0 |
Researchers at the University of Illinois at Chicago College of Medicine will study gender differences in how the heart uses and stores fat—its main energy source—and how changes in fat metabolism play ...
Medical research 6 hours ago | not rated yet | 0
Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too ...
Medical research 22 hours ago | 5 / 5 (2) | 0 |
38 minutes ago | not rated yet | 0 |
The decision to limit life support in patients in the intensive care unit (ICU) appears to be significantly influenced by physician practices and/or the culture of the hospital, suggests new findings from researchers at the ...
56 minutes ago | not rated yet | 0
Children with obstructive sleep apnea who had a common surgery to remove their tonsils and adenoids showed notable improvements in behavior, quality of life and other symptoms compared to those treated with "watchful waiting" ...
56 minutes ago | not rated yet | 0
3 hours ago | 4 / 5 (3) | 0 |
(Medical Xpress)—Despite spending billions of dollars on research and development, drug companies have been unable to come up with effective treatments for dementia and Alzheimer's Disease (AD). Now, A. ...
1 hour ago | 4.7 / 5 (3) | 0 |
Children with autism showed significant improvement after six months of simple sensory exercises at home using everyday items such as scents, spoons and sponges, according to UC Irvine neurobiologists.
1 hour ago | not rated yet | 0 |