New research dashes notions of benign brain plaque
(Medical Xpress) -- The time may have come to scrub the idea that brain plaque deposits of protein that clog passages between brain cells might not be all that bad.
University of Florida researchers have discovered that people with no signs of dementia during their lives, even though their brains contained the debris typical of Alzheimers disease, probably would have experienced health problems had they lived longer, according to a study to appear this week in the open access journal Alzheimers Research & Therapy.
Scientists suspect patients who experience relatively few cognitive problems even with a substance called amyloid beta protein accumulating in their brains the hallmark of Alzheimers disease might collect a less toxic form of the so-called brain plaque.
But UF College of Medicine scientists with colleagues from the Mayo Clinic in Jacksonville found few differences when they compared the postmortem brain tissue of Alzheimers patients with that from people who accumulated plaque without symptoms, a condition known as pathological aging.
Pathological aging may be early Alzheimers disease rather than a benign form of amyloid protein deposition, or it may be patients with PA are resistant to the toxic effects of the amyloid plaques, said Dr. Todd Golde, director of the UFs Center for Translational Research in Neurodegenerative Disease. It will be important to understand the differences between these two neurodegenerative pathologies in treatment and prevention efforts.
Alzheimers disease is characterized by severe loss of neurons in brain regions important for learning and memory because of overproduction of amyloid beta protein. In a healthy brain, these protein fragments are broken down and eliminated. But when they accumulate, scientists believe amyloid plaque interferes with the brains ability to generate new cells and contributes to tangles twisted masses of protein fibers within the brain cell.
The researchers found similar amounts of insoluble amyloid in Alzheimers and pathologically aged brain tissue, with elevated levels in both types of abnormal tissue compared with healthy brain tissue. Researchers also found a great deal of similarity and overlap in the subtypes of amyloid protein, according to Golde, who is also affiliated with UFs McKnight Brain Institute.
Experimental models suggest that therapies that target these proteins may be effective in preventing or delaying disease development. Without treatment or prevention breakthroughs, a projected 7.7 million patients in the U.S. will have Alzheimers by 2030, according to the Alzheimers Association. That number will grow to between 11 million and 16 million by 2050.
Provided by University of Florida
- Falls may be early sign of Alzheimer's Jul 18, 2011 | not rated yet | 0
- Putting top brains to the test with Alzheimer's protein Jan 31, 2011 | not rated yet | 0
- New discovery in Alzheimer's protein puzzle May 14, 2012 | not rated yet | 0
- Alzheimer's patients may get help from drug originated for diabetes Feb 04, 2011 | not rated yet | 0
- Malfunctioning protein a cause of Alzheimer's plaques Jun 30, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
gravity is std. therefore can we rate a 'mass at height' by watts?
3 hours ago For example.... wind turbines are primarily listed by their wattage (1.5MW etc.) Presumably their output is varied according to rotational speed, so...
Calculating on-axis elements of a solenoid
15 hours ago I wanted to mention that this solenoid has many winds over many layers. The thickness of the windings is 2.4 inches coming off of the engineering...
latitude & longitude & air pressure
17 hours ago Hi there, I have a peculiar question. Imagine that you are in a earth position, obtained by google, that gives you the latitude and longitude....
Differences of Classical Mechanics when learned with Calc vs algebra?
20 hours ago what are the differences? Every example I find usually has a derivative or integral or some kind of calculus defined concept that seems to make it...
what is the distance traveled
May 22, 2013 A rough sketch of experiment. Image: http://i43.tinypic.com/14t4sk5.png the red dots represent a side view of path traveled, F is downward force...
Image of a Convex Lens Cut in Half Horizontally
May 22, 2013 Hello everyone, A friend of mine came up with this question in class and I really do not have a good answer. Suppose you have a convex lens...
- More from Physics Forums - Classical Physics
More news stories
A potentially ground-breaking human drug trial is currently underway, which aims to discover whether blood pressure medication can slow or halt the progression of Alzheimer's Disease (AD). This is the latest ...
Alzheimer's disease & dementia 2 hours ago | not rated yet | 0
Researchers at USC have found that a class of pharmaceuticals can both prevent and treat Alzheimer's Disease in mice.
Alzheimer's disease & dementia May 21, 2013 | 5 / 5 (7) | 0 |
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons ...
Alzheimer's disease & dementia May 20, 2013 | 5 / 5 (4) | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
Alzheimer's disease & dementia May 19, 2013 | 5 / 5 (3) | 0 |
The devastating effect of Alzheimer's disease on bilingual people has been thrown into focus in Canada, where the sudden loss of a second language can leave sufferers feeling like strangers in their own country.
Alzheimer's disease & dementia May 19, 2013 | not rated yet | 0
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
1 hour ago | 5 / 5 (2) | 0 |
Gaucher disease causes debilitating and sometimes fatal neurodegeneration in early childhood. Recent studies have uncovered a link between the mutations responsible for Gaucher disease and an increased risk ...
54 minutes ago | not rated yet | 0 |
Spanish researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today ...
1 hour ago | not rated yet | 0
Treating pediatric leukemia patients with a liposomal formulation of anthracycline-based chemotherapy at a more intense-than-standard dose during initial treatment may result in high survival rates without causing any added ...
58 minutes ago | not rated yet | 0
Family caregivers of older adults with dementia are less stressed and their moods are improved on days when dementia patients receive adult day services (ADS), according to Penn State researchers.
57 minutes ago | not rated yet | 0