ECO: New weight loss drug effective in advanced obesity

May 14, 2012
ECO: new weight loss drug effective in advanced obesity

(HealthDay) -- A new combination treatment of controlled-release phentermine/topiramate (PHEN/TPM CR) leads to significantly greater weight loss than a placebo even in individuals with significant obesity-related comorbidities, according to a study presented at the European Congress on Obesity, held from May 9 to 11 in Lyon, France.

Stephan Rössner, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleagues randomly assigned 2,487 subjects to placebo or one of two doses of PHEN/TPM CR: 7.5 mg/46 mg (7.5/46) or 15 mg/92 mg (15/92) for 56 weeks. Subjects were categorized according to the Edmonton Staging System (EOSS), which measures obesity-related morbidity, with most subjects having weight-related chronic disease (2,170 individuals) or established end-organ damage (180 individuals).

The researchers found that PHEN/TPM treatment was associated with significantly greater compared with placebo across all EOSS categories. Weight loss increased in a dose-response manner and ranged from 1.5 to 2.3 percent for placebo, 6.8 to 8.6 percent for 7.5/46 PHEN/TPM, and 9.5 to 10.5 percent for 15/92 PHEN/TPM. Dry mouth, constipation, and paraesthesia were the most common adverse events.

"In this study, subjects with established comorbidities treated with PHEN/TPM CR showed significantly greater weight loss than regardless of baseline EOSS," Rossner and colleagues conclude.

Several authors disclosed financial ties to pharmaceutical companies, including Vivus, which manufactures phentermine/topiramate and funded the study.

More information: More Information

Related Stories

Experimental drug achieves unprecedented weight loss

April 11, 2011

An investigational combination of drugs already approved to treat obesity, migraine and epilepsy produced up to a 10 percent weight loss in obese individuals participating in a one-year clinical trial, according to researchers ...

Topiramate may have benefit as a weight-loss drug

June 6, 2011

The drug topiramate can help people lose weight as long as they can tolerate the side effects, according to authors of a new study that reviewed the medical literature. Brazilian researchers will present the results Saturday ...

Dapagliflozin aids glycemic control in type 2 diabetes

March 20, 2012

(HealthDay) -- For patients with inadequately controlled type 2 diabetes, treatment with dapagliflozin is associated with improved glycemic control, stabilized insulin dosing, and weight reductions, according to research ...

Recommended for you

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.