Family history of Alzheimer's affects functional connectivity
May 26, 2012 in Alzheimer's disease & dementia
(HealthDay) -- Cognitively normal individuals with a family history of late-onset Alzheimer's disease (AD) may display lower resting state functional connectivity in the default mode network (DMN) of the brain, and this effect is detectable even in those who do not carry the apolipoprotein E (APOE) ε4 allele, according to a study published online May 9 in the Annals of Neurology.
Liang Wang, M.D., of Washington University in St. Louis, and colleagues conducted a cohort study of 348 cognitively normal participants with or without a family history of late-onset AD to examine the effect of family history on the integrity of the DMN, and whether this effect is detectable in APOE ε4 noncarriers. Resting state functional connectivity magnetic resonance imaging was used to assess the integrity of the DMN.
The researchers found that patients with a family history of late-onset AD displayed reduced functional connectivity between nodes of the DMN, specifically the posterior cingulate cortex and medial temporal cortex. This was not attributable to structural atrophy in the medial temporal lobe. This effect was also seen in noncarriers of the APOE ε4 allele.
"Unknown genetic factors, embodied in a family history of late-onset AD, may affect DMN integrity prior to cognitive impairment," the authors conclude.
Several authors disclosed financial ties to the pharmaceutical industry related to the study of dementia treatments.
More information: Abstract
Full Text (subscription or payment may be required)
Journal reference:
Annals of Neurology
Copyright © 2012 HealthDay. All rights reserved.
-
Active lifestyle associated with less Alzheimer disease-related brain change among persons with APOE epsilon4 genotype
Jan 16, 2012 |
not rated yet |
0
-
Activity in brain networks related to features of depression
Apr 03, 2012 |
not rated yet |
0
-
Study predicts risk of memory loss in healthy, older adults
Jan 19, 2011 |
not rated yet |
0
-
New study finds healthy children of Alzheimer patients show early brain changes
Jul 29, 2008 |
not rated yet |
0
-
Engineered mice provide insight into Alzheimer's disease
Jan 17, 2008 |
not rated yet |
0
-
Motion perception revisited: High Phi effect challenges established motion perception assumptions
Apr 23, 2013 |
3 / 5 (2) |
2
-
Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update)
Apr 02, 2013 |
4.5 / 5 (11) |
5
-
The visual system as economist: Neural resource allocation in visual adaptation
Mar 30, 2013 |
5 / 5 (2) |
9
-
Separate lives: Neuronal and organismal lifespans decoupled
Mar 27, 2013 |
4.9 / 5 (8) |
0
-
Sizing things up: The evolutionary neurobiology of scale invariance
Feb 28, 2013 |
4.8 / 5 (10) |
14
-
Change in momentum when a body is thrown up and falls back down.
3 hours ago
-
change in speed and wavelength of light while travelling from one med
3 hours ago
-
Calculus of Variation - Classical Mechanics
6 hours ago
-
Frictional Force Equation Doesn't Make Sense
6 hours ago
-
Calculating Steam Pressure in Closed Container
11 hours ago
-
Learning curve of Electromagnetism?
17 hours ago
- More from Physics Forums - Classical Physics
More news stories
Study identifies new approach to improving treatment for MS and other conditions
(Medical Xpress)—Working with lab mice models of multiple sclerosis (MS), UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved ...
Alzheimer's disease & dementia
May 17, 2013 |
5 / 5 (2) |
0
|
Nonmelanoma skin cancer tied to lower Alzheimer's risk
(HealthDay)—Older individuals with nonmelanoma skin cancer (NMSC) seem to have a significantly reduced risk of developing Alzheimer's disease (AD), according to a study published online May 15 in Neurology.
Alzheimer's disease & dementia
May 16, 2013 |
5 / 5 (1) |
0
Skin cancer may be linked to lower risk of Alzheimer's disease
People who have skin cancer may be less likely to develop Alzheimer's disease, according to new research published in the May 15, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology. The li ...
Alzheimer's disease & dementia
May 15, 2013 |
5 / 5 (1) |
0
|
Alzheimer's markers predict start of mental decline
(Medical Xpress)—Scientists at Washington University School of Medicine in St. Louis have helped identify many of the biomarkers for Alzheimer's disease that could potentially predict which patients will develop the disorder ...
Alzheimer's disease & dementia
May 14, 2013 |
3 / 5 (1) |
0
|
Scientists develop drug that slows Alzheimer's in mice
A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer's disease in aged mice following short-term treatment. The findings, ...
Alzheimer's disease & dementia
May 13, 2013 |
4.2 / 5 (5) |
0
|
Consuming coffee linked to lower risk of detrimental liver disease, study finds
Regular consumption of coffee is associated with a reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, Mayo Clinic research shows. The findings were being presented at the Digestive Disease ...
Ketamine shows significant therapeutic benefit in people with treatment-resistant depression
Patients with treatment-resistant major depression saw dramatic improvement in their illness after treatment with ketamine, an anesthetic, according to the largest ketamine clinical trial to-date led by researchers from the ...
Research examines new methods for managing digestive health
Research presented at Digestive Disease Week (DDW) explores new methods for managing digestive health through diet and lifestyle.
New smartphone application improves colonoscopy preparation
The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in ...
New research identifies practice changes to improve value and quality of GI procedures
There are significant cost and risk factors associated with two procedures commonly used to diagnose or treat gastrointestinal problems, according to research presented at Digestive Disease Week (DDW).
New research identifies risks, interventions for children's GI health
An increasing number of U.S. children are experiencing gastrointestinal issues that require interventions to resolve, according to research presented at Digestive Disease Week (DDW).
