Health-related QoL evaluated for children with brain tumors

May 9, 2012
Health-Related QoL evaluated for children with brain tumors

(HealthDay) -- In children and adolescents with brain tumors treated with proton radiation, health-related quality of life (HRQoL) scores are affected by both disease type and treatment, with assessments made by the patients correlating well with those of their parents, according to a study published online May 7 in the Journal of Clinical Oncology.

Karen A. Kuhlthau, Ph.D., of Massachusetts General Hospital in Boston, and colleagues conducted a prospective study to evaluate the HRQoL of 142 , aged 2 to 18 years, with brain tumors, who were treated with proton radiotherapy. The HRQoL assessments were made using the PedsQL core, brain tumor, and cancer modules, with scores ranging from 0 to 100. Both child self-report (CSR) and parent proxy report (PPR) were utilized.

For the core and brain tumor modules, the researchers found that the ratings of HRQoL from parents and children correlated well, although parent reports were generally lower than those of their children (74.8 and 78.1, respectively, for CSR and 67.0 and 74.8, respectively, for PPR). Disease type was associated with PPR core total HRQoL score at the start of treatment, with the lowest scores for medulloblastoma or primitive neuroectodermal tumors and the highest scores for low-grade glioma or other low-grade neoplasms. HRQoL was lower for those also receiving craniospinal irradiation and chemotherapy.

"This prospective study of children with treated with proton radiation demonstrates the effect on HRQoL of disease type and intensity of treatment," the authors write.

One author disclosed to ProCure.

Explore further: Adults with arthritis suffer with poorer health related quality of life

More information: Abstract
Full Text (subscription or payment may be required)
Editorial

Related Stories

Recommended for you

Researchers thwart cancer cells by triggering 'virus alert'

August 27, 2015

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.