Exercise does not improve lipoprotein levels in obese patients with fatty liver disease

New research found that moderate exercise does not improve lipoprotein concentrations in obese patients with non alcoholic fatty liver disease (NAFLD). Results published in the June issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, report that moderate physical activity produces only a small decrease in triglyceride and alanine transaminase (ALT) levels.

Obesity is a rampant health concern worldwide. In fact, the (WHO) reported in 2008 that 1.5 billion people, age 20 and older, were overweight, and of these, 200 million men and roughly 300 million women were considered obese. One common complication of obesity is NAFLD, which causes metabolic abnormalities that can lead to severe liver disease. Previous research found that weight loss and regular exercise improved metabolic disturbances associated with NALFD.

Evidence of the effects of on NAFLD, independent of weight loss, is limited. To further investigate, Dr. Samuel Klein and colleagues from the Washington University School of Medicine in St. Louis, Mo. evaluated the impact of physical activity programs recommended by the Department of Health and Human Services on ALT, cholesterol and in obese NAFLD patients.

This single-center trial included 18 obese participants with NAFLD who were randomized to 16 weeks of 30 to 60 minutes of moderate exercise at 5 days per week with 12 participating in physical activity and 6 in the control group. Researchers analyzed the impact of exercise on intrahepatic triglyceride (IHTG), very low density lipoproteins (VLDL), and apolipoprotein B-100 (apoB-100).

Analysis shows that exercise decreased IHTG content by 10%, but did not change total body weight or body fat percentage. Total body weight prior to exercise program was 103.1 kg and 102.9 kg after physical activity; body fat was 38.9 before and 39.2 after exercise training. The authors found no change in liver lipoprotein levels (VLDL or apoB-100) in obese NAFLD patients who engaged in physical activity training.

"Our data demonstrate that a moderate intensity exercise program followed by obese patients with NALFD causes a small decrease in IHTG content, even when body weight and total body fat mass are maintained," concludes Dr. Klein. "Current exercise recommendations seem to have only a modest effect on triglycerides and ALT levels, suggesting that improvement in lipoprotein metabolism and fatty liver (steatosis) may be due to weight loss and not increased physical activity." The authors suggest further study of the impact of moderate exercise on IHTG content in those with NAFLD.

More information: "Randomized Trial of Exercise Effect on Intrahepatic Triglyceride Content and Lipid Kinetics in Nonalcoholic Fatty Liver Disease." Shelby Sullivan, Erik P. Kirk, Bettina Mittendorfer, Bruce W. Patterson and Samuel Klein. Hepatology; April 25, 2012 (DOI: 10.1002/hep.25548); Print Issue Date: June 2012

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Where Ebola battles are won

7 hours ago

(HealthDay)—Four hospitals that are home to advanced biocontainment facilities have become America's ground zero in the treatment of Ebola patients.

Depression tied to worse lumbar spine surgery outcomes

9 hours ago

(HealthDay)—Depressive symptoms are associated with poorer long-term outcome in patients undergoing surgery for lumbar spinal stenosis (LSS), according to research published in the Oct. 1 issue of The Sp ...

Ebola death toll edging to 4,900 mark: WHO

10 hours ago

The death toll in the world's worst-ever Ebola outbreak has edged closer to 4,900, while almost 10,000 people have now been infected, new figures from the World Health Organization showed Wednesday.

US to track everyone coming from Ebola nations

10 hours ago

U.S. authorities said Wednesday that everyone traveling into the U.S. from Ebola-stricken nations will be monitored for symptoms for 21 days. That includes returning American aid workers, federal health employees ...

User comments