A marker in the lining of the lungs could be useful diagnostic technique for lung cancer screening

May 15, 2012

The most recent research released in June's Journal of Thoracic Oncology says molecular biomarkers in the tissue and fluid lining the lungs might be an additional predictive technique for lung cancer screening.

Since the National Lung Screening Trial found that 96.4 percent of the positive CT screening results were false positive, scientists have been looking for ways to more accurately diagnose patients. This research focused on a way to determine if the nodules detected by the CT screening, are in fact malignant or benign.

The study presented in the June 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) collected endobronchial epithelial-lining fluid (ELF) near a lung nodule using bronchoscopic microsampling, which is a less invasive procedure compared to surgery.

After studying 142 ELF samples from 71 patients with pulmonary nodules, some cancerous, others non cancerous, the authors conclude that, "TNC (tenasin-C) gene expression and the nodule size are two independent factors that improved the prediction of lung cancer. However this finding has to be verified in larger cohorts."

The authors point out that in previous research, " like CEA and CYFRA were found to be in higher abundance in ELF close to the small peripheral when compared to the contralateral site or benign cases."

Explore further: Panel of serum biomarkers may reduce number of lung biopsies needed

Related Stories

Recommended for you

Elephants provide big clue in fight against cancer

October 9, 2015

Carlo Maley spends his time pondering pachyderms—and cactuses and whales, and a wide array of non-human species—all in pursuit of the answer to this question: Why do some life forms get cancer while others do not?

Compound doubles up on cancer detection

October 8, 2015

Tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer, according to a study published last week in the Proceedings of the ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.