Pathological aging brains contain the same amyloid plaques as Alzheimer's disease
Pathological aging (PA) is used to describe the brains of people which have Alzheimer's disease (AD)-like pathology but where the person showed no signs of cognitive impairment whilst they were alive. New research, published in BioMed Central's open access journal Alzheimer's Research & Therapy, shows that PA and AD brains contain similar amyloid β (Aβ) plaques and that while on average AD brains contain more Aβ there was considerable overlap in Aβ subtypes. These results suggest that PA may simply be an early stage of AD.
AD is the most common cause of dementia. It can result in loss of memory, mood changes, and cause problems with communication and reasoning. The disease is characterized by large numbers of Ab; plaques, tangles and neuroinflammation changes within the brain. People with PA also have Ab; plaques, but less neuroinflammation and other AD specific brain changes, so it has been previously suggested that the Ab; plaques in PA are different and somehow less toxic than those in AD.
Researchers from University of Florida and Mayo Clinic, supported by the National Institute of Health, compared post-mortem brain tissue from people with AD, PA, and controls. When they looked at the type and amount of Ab; they found that while both AD and PA had elevated levels of Ab; on average levels were slightly lower in PA.
Comparing subtypes of Ab demonstrated that there was a great deal of similarity and overlap between AD and PA and biochemical analysis showed both AD and PA have dramatically, but equivalent, higher levels of insoluble Ab, compared to controls. Further studies showed that that there were really no major differences between the accumulated Ab in both AD and PA.
Dr Todd Golde, who coordinated the research, commented, "We found a high degree of overlap in Ab levels, profiles, and solubility, between the brains of people with PA and AD. While there might be some subtle differences in Ab, it seems that PA may represent an early stage of AD rather than a benign form of Ab deposition, and that if they live long enough people with PA will go on to develop AD. We hope that understanding the differences between PA and AD will provide new ways to help protect the brain and promote the development of AD therapeutics."
More information: Overlapping profiles of abeta peptides in the Alzheimer's disease and pathological aging brains Brenda D Moore, Paramita Chakrabarty, Yona Levites, Tom L Kukar, Ann-Marie Baine, Tina Moroni, Thomas B Ladd, Pritam Das, Dennis W Dickson and Todd E Golde Alzheimer's Research & Therapy (in press)
Journal reference: Alzheimer\'s Research & Therapy
Provided by BioMed Central
- Overlooked peptide reveals clues to causes of Alzheimer's disease Jul 03, 2011 | not rated yet | 0
- Soluble amyloid beta-protein implicated in Alzheimer's disease Sep 02, 2010 | not rated yet | 0
- Inflammatory mediator enhances plaque formation in Alzheimer's disease Sep 07, 2011 | not rated yet | 0
- Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain Dec 24, 2008 | not rated yet | 0
- Neuroimaging may shed light on how Alzheimer's disease develops Jan 11, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Is energy convertible to matter?
1 hour ago Can we convert energy to matter?
Rotating electron as a dipole is this right?
3 hours ago An electron as shown by the Stern Gerlach experiment behaves like a dipole (albeit only in one of two states). I have been trying to figure out how...
Dipole term in multipole expansion
7 hours ago Hi. I'm having some difficult in understanding something about the dipole term in a multipole expansion. Griffiths writes the expansion as a sum of...
Bubbles in a Pre-Boiling/Boiling pot of water
8 hours ago How is it that bubbles form on the bottom of a surface of a pot of boiling water? I think that there is probably an elementary answer to this...
Assumptions of Griffith's fracture theory
19 hours ago Any experts on Griffith's fracture theory? I am studying the subject and I am having hard time finding out if the theory is valid for all possible...
Current leading voltage or vice versa concept
20 hours ago Hello, I was wondering if there is a conceptual explanation for when current leads voltage or vice versa for capacitors or inductors with AC...
- More from Physics Forums - Classical Physics
More news stories
Researchers at USC have found that a class of pharmaceuticals can both prevent and treat Alzheimer's Disease in mice.
Alzheimer's disease & dementia 7 hours ago | 5 / 5 (2) | 0 |
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons ...
Alzheimer's disease & dementia May 20, 2013 | 5 / 5 (4) | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
Alzheimer's disease & dementia May 19, 2013 | 5 / 5 (3) | 0 |
The devastating effect of Alzheimer's disease on bilingual people has been thrown into focus in Canada, where the sudden loss of a second language can leave sufferers feeling like strangers in their own country.
Alzheimer's disease & dementia May 19, 2013 | not rated yet | 0
(Medical Xpress)—Working with lab mice models of multiple sclerosis (MS), UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved ...
Alzheimer's disease & dementia May 17, 2013 | 5 / 5 (2) | 0 |
(Medical Xpress)—Native peoples in regions where cameras are uncommon sometimes react with caution when their picture is taken. The fear that something must have been stolen from them to create the photo ...
10 hours ago | 4 / 5 (4) | 0 |
(Medical Xpress)—Despite spending billions of dollars on research and development, drug companies have been unable to come up with effective treatments for dementia and Alzheimer's Disease (AD). Now, A. ...
8 hours ago | 4.8 / 5 (6) | 0 |
An experimental sleeping pill from US drug company Merck is effective at helping people fall and stay asleep, according to reviewers at the US Food and Drug Administration, which could soon approve the new drug.
3 hours ago | 5 / 5 (1) | 0
Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May ...
4 hours ago | 5 / 5 (3) | 0 |
A drug commonly used to treat depression and anxiety may improve a stress-related heart condition in people with stable coronary heart disease, according to researchers at Duke Medicine.
5 hours ago | not rated yet | 0 |
Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understanding what goes wrong in diabetes.
9 hours ago | 4.8 / 5 (4) | 0 |