Phylogenomic analysis reveals origin, spread of MRSA clone

May 21, 2012
Phylogenomic analysis reveals origin, spread of MRSA clone

(HealthDay) -- Phylogenomic analysis has revealed details about the emergence and transmission of a major methicillin-resistant Staphylococcus aureus (MRSA) clone, EMRSA-16, according to research published online May 14 in the Proceedings of the National Academy of Sciences.

Paul R. McAdam, from the University of Edinburgh in the United Kingdom, and colleagues performed a Bayesian phylogenetic reconstruction on the basis of genome sequences from 87 Staphylococcus aureus isolates. The isolates were collected from patients in three continents over a 53-year period and included 60 isolates of the pandemic EMRSA-16 clone and 27 additional clonal complex 30 (CC30) isolates.

The researchers found that there was a shared by the three major pandemic clones, originating from the CC30 lineage (phage type 80/81, Southwest Pacific, and EMRSA-16), which existed more than 100 years ago. In contrast, the hospital-associated EMRSA-16 clone likely emerged 35 years ago. A genome-wide analysis of CC30 revealed molecular correlates of hospital- or community-associated pandemics, including mobile genetic elements and nonsynonymous mutations impacting both and virulence. Phylogeographic analysis demonstrated that the spread of EMRSA-16 within the United Kingdom was from hospitals in large population centers in London and Glasgow to regional health care settings.

"Taken together, the high-resolution phylogenomic approach used resulted in a unique understanding of the emergence and transmission of a major MRSA clone and provided molecular correlates of its hospital adaptation," the authors write.

ARK-Genomics at the Roslin Institute performed sequencing services for the study.

Explore further: MRSA superbug spreads from big city hospitals to regional health centers, study suggests

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study finds fire stations contaminated with MRSA

June 1, 2011

MRSA transmission may be occurring in fire stations, according to a study published in the June issue of the American Journal of Infection Control, the official publication of APIC – the Association for Professionals ...

MRSA tailors virulence mechanisms to the hospital setting

April 25, 2012

(Medical Xpress) -- In the hospital environment where antibiotic usage is extremely high, it seems that healthcare associated methicillin resistant Staphylococcus aureus (MRSA) has cleverly adapted for survival.

Recommended for you

Zika virus infection alters human and viral RNA

October 20, 2016

Researchers at University of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and human genetic material. These modifications—chemical tags known as ...

Food-poisoning bacteria may be behind Crohn's disease

October 19, 2016

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University.

Neurodevelopmental model of Zika may provide rapid answers

October 19, 2016

A newly published study from researchers working in collaboration with the Regenerative Bioscience Center at the University of Georgia demonstrates fetal death and brain damage in early chick embryos similar to microcephaly—a ...

Scientists uncover new facets of Zika-related birth defects

October 17, 2016

In a study that could one day help eliminate the tragic birth defects caused by Zika virus, scientists from the Florida campus of The Scripps Research Institute (TSRI) have elucidated how the virus attacks the brains of newborns, ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.