Phylogenomic analysis reveals origin, spread of MRSA clone

Phylogenomic analysis reveals origin, spread of MRSA clone

(HealthDay) -- Phylogenomic analysis has revealed details about the emergence and transmission of a major methicillin-resistant Staphylococcus aureus (MRSA) clone, EMRSA-16, according to research published online May 14 in the Proceedings of the National Academy of Sciences.

Paul R. McAdam, from the University of Edinburgh in the United Kingdom, and colleagues performed a Bayesian phylogenetic reconstruction on the basis of genome sequences from 87 Staphylococcus aureus isolates. The isolates were collected from patients in three continents over a 53-year period and included 60 isolates of the pandemic EMRSA-16 clone and 27 additional clonal complex 30 (CC30) isolates.

The researchers found that there was a shared by the three major pandemic clones, originating from the CC30 lineage (phage type 80/81, Southwest Pacific, and EMRSA-16), which existed more than 100 years ago. In contrast, the hospital-associated EMRSA-16 clone likely emerged 35 years ago. A genome-wide analysis of CC30 revealed molecular correlates of hospital- or community-associated pandemics, including mobile genetic elements and nonsynonymous mutations impacting both and virulence. Phylogeographic analysis demonstrated that the spread of EMRSA-16 within the United Kingdom was from hospitals in large population centers in London and Glasgow to regional health care settings.

"Taken together, the high-resolution phylogenomic approach used resulted in a unique understanding of the emergence and transmission of a major MRSA clone and provided molecular correlates of its hospital adaptation," the authors write.

ARK-Genomics at the Roslin Institute performed sequencing services for the study.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Study finds fire stations contaminated with MRSA

Jun 01, 2011

MRSA transmission may be occurring in fire stations, according to a study published in the June issue of the American Journal of Infection Control, the official publication of APIC – the Association for Professionals in Inf ...

MRSA head and neck infections increase among children

Jan 19, 2009

Rates of antibiotic-resistant head and neck infections increased in pediatric patients nationwide between 2001 and 2006, according to a report in the January issue of Archives of Otolaryngology-Head & Neck Surgery, one of ...

Recommended for you

Chikungunya fever identified in the United States

2 hours ago

(HealthDay)—Chikungunya fever is being seen in travelers returning to the United States from affected regions and should be considered as a diagnosis for febrile travelers, according to an ideas and opinions ...

Boost in quest for TB breath test

5 hours ago

A simple breath test may one day show whether someone has a strain of tuberculosis that will respond to a frontline antibiotic, or a drug-resistant type, scientists said Tuesday.

Three more dead from Legionnaire's disease in Spain

5 hours ago

Three more people have died from Legionnaire's disease in Catalonia in northeastern Spain, officials said Tuesday, bringing to seven the death toll from the lung infection in the region in just over a week.

User comments