Rethinking science on pandemic-potential viruses

By Ashley Yeager
Electron micrograph of influenza A virus. Credit: Centers for Disease Control, Erskine Palmer)

Making mutant forms of bird flu and publishing the results caused a major squawk in the public and in the political and scientific communities over the last year.

The issue was whether the new mutants could ward off a major pandemic of or start one, explained Stephanie Holmer, a graduate student in Duke’s Department of Cell Biology.

She raised the issue during the May 18 meeting of the Science and Society Journal Club.

The row began when researchers at the University of Wisconsin-Madison and the Erasmus Medical Center in the Netherlands independently tweaked strains of the H5N1 virus, commonly named the bird flu. The strains, the teams report, are more easily transmitted between ferrets, the lab-double for humans.

“The fear was that if the mutant forms of the virus got out of the lab, bioterrorists could use them to make a super-virus and start a . But there was not any guarantee that what the scientists had was a weapon. The mutant strains weren’t even that efficient at killing a ferret,” Holmer said.

During the forum, about a dozen students and faculty from departments across campus debated whether this kind of research should have been done, if journal editors should publish the full results and what can be done to prevent future squawks about similar types of research.

Scientists want to study H5N1 to find out how fast the virus mutates and how virulent those strains are in mammals, including humans. So far, outbreaks of the non-mutant form of the bird in humans have been limited. The cases, about 100 to 200 from 2003-2012, have occurred most often in Indonesia, Egypt and Vietnam, according to statistics from the World Health Organization.

In two separate papers, the teams from Madison and the Netherlands reported the strains of H5N1 that seemed to be more virulent in ferrets. The Madison team submitted its paper to Nature; the Netherlands’ team submitted to Science. Both papers came under government scrutiny before they were published because the methods in each could potentially be misused to make a bioweapon.

But the researchers had already presented their data at conferences, and they had institutional approval to initiate the experiments, facts that led Subhashini Chandrasekharan, co-coordinator of the journal club, to wonder aloud why it took until the point of publication to prompt a government and scientific scuffle over the experiments and the results.

“I’m not a virologist, but I don’t find any reason that the study should not be done or that the results should not be published. The jump of this virus from birds to humans is going to happen. It’s only a matter of time. If we already understand the mutations, then we’ll be faster at finding treatments and vaccines,” Chandrasekharan said.

She added that if a bioterrorist is going to make a weapon from a , it didn’t seem likely that they’d need the papers, which were finally approved for publication on April 20, to make the mutations. They’d do it anyway, she said, explaining that preventing publication was probably not going to be “the wall” to stop a terrorist from plotting an attack.

That issue, of course, raises another whole set of squawks.

add to favorites email to friend print save as pdf

Related Stories

Dutch okays mutant bird flu study's publication

Apr 27, 2012

The Dutch government on Friday gave a top scientist the green light to publish a research paper in the United States on a mutant killer flu virus, following approval by a US panel of experts.

Bird flu can transmit in mammals, study finds

May 04, 2012

In a long-awaited study that helped prompt a contentious debate over the wisdom of conducting research that has the potential to help as well as harm, scientists reported Wednesday that they had engineered a mutant strain ...

Old drug may become new bird flu weapon

Mar 15, 2006

Amantadine, a generic drug created in the 1970s to treat seasonal flu might become a new weapon to use along with Tamiflu if a bird flu pandemic occurs.

Panel backs sharing studies of lab-made bird flu

Mar 30, 2012

(AP) -- The U.S. government's biosecurity advisers said Friday they support publishing research studies showing how scientists made new easy-to-spread forms of bird flu because the studies, now revised, don't reveal details ...

Recommended for you

Ebola death toll passes 7,500

3 hours ago

More than 7,500 people have now died from the Ebola virus, as the number of cases climbs towards 20,000, the World Health Organization said Monday.

Ebola-infected Italian doctor 'recovering'

3 hours ago

An Italian doctor who contracted Ebola in west Africa is recovering but is still in an isolation unit, the specialist clinic in Rome treating him said Monday.

Restrictions lifted at British bird flu farm

Dec 21, 2014

Britain on Sunday lifted all restrictions at a duck farm in northern England after last month's outbreak of H5N8 bird flu, the same strain seen in recent cases across Europe.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.