Study examines retinal vessel diameter and CVD risk in African Americans with type 1 diabetes
Among African Americans with type 1 diabetes mellitus, narrower central retinal arteriolar equivalent (average diameter of the small arteries in the retina) is associated with an increased risk of six-year incidence of any cardiovascular disease and lower extremity arterial disease, according to a report in the May issue of Archives of Ophthalmology.
"Retinal arteriolar narrowing has long been described as one of the characteristic changes associated with hypertension and cardiovascular disease (CVD)," the authors write as background information in the study.
Monique S. Roy, M.D., of the University of Medicine and Dentistry, New Jersey Medical School, The Institute of Ophthalmology and Visual Science, Newark, N.J., and colleagues, sought to evaluate the relationship between retinal arteriolar and venular diameter and the six-year incidence of cardiovascular disease and mortality among African Americans with type 1 diabetes mellitus.
The study included 468 African Americans with type 1 diabetes mellitus who participated in the New Jersey 725 and had undergone a six-year follow-up examination. At both study entry and follow-up, hypertension and presence of heart disease, stroke or lower extremity arterial disease (LEAD) were documented and were confirmed by review of hospital admission and medical records.
During the six-year follow-up, 59 patients developed CVD (37 with heart disease or stroke and 22 with LEAD), and 79 developed hypertension. The authors found that narrower central arteriolar equivalent (CRAE) at baseline was significantly and independently associated with six-year incidence of any cardiovascular disease and LEAD, as well as all cause mortality, while a larger retinal venular diameter was associated with six-year incidence of hypertension.
"In summary, results of the present study indicate that, in African Americans with type 1 DM, narrower CRAE is an independent predictor of the six-year incidence of any CVD and LEAD, and larger central retinal venular equivalent [CRVE] is an independent predictor of the incidence of hypertension," the authors conclude.
More information: Arch Ophthalmol. 2012;130:561-567
Journal reference: JAMA Ophthalmology
Provided by JAMA and Archives Journals
- Retinal microvascular changes associated with disability in daily activities among older adults Nov 14, 2011 | not rated yet | 0
- Diabetic eye disease more severe in African-Americans who consume more calories, sodium Jan 11, 2010 | not rated yet | 0
- Kids' 'screen time' linked to early markers for cardiovascular disease Apr 20, 2011 | not rated yet | 0
- High blood pressure, high cholesterol may be associated with retinal vascular disease May 12, 2008 | not rated yet | 0
- Stroke incidence higher among patients with certain type of retinal vascular disease Mar 14, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Assumptions of Griffith's fracture theory
4 hours ago Any experts on Griffith's fracture theory? I am studying the subject and I am having hard time finding out if the theory is valid for all possible...
Current leading voltage or vice versa concept
6 hours ago Hello, I was wondering if there is a conceptual explanation for when current leads voltage or vice versa for capacitors or inductors with AC...
Angular Frequency of AC voltage
9 hours ago Hello, I am wondering, what is the physical interpretation of the angular frequency of AC voltage? I don't see the physicality of what the angle...
Modeling Rigid Body - Unsure about Euler angles and angular velocity
9 hours ago I'm modeling a single 3D rigid body in preparation for some more complicated modeling in order to gain a better understanding of Euler angles, the...
Function for a bullet's path
10 hours ago I've been mulling this over all weekend, and I've decided to get some help on this. The problem is writing a function to describe a bullet's path....
Elementary questions relating to Newton's laws of motion
12 hours ago i) If a wall breaks when it gets hit by a cannonball, did the wall exert an equal and opposite force on the cannonball? ii) Would the force...
- More from Physics Forums - Classical Physics
More news stories
(Medical Xpress)—Exposure to sunshine as a small child is crucial to the development of a healthy eye according to results of long-term myopia study conducted by University of Sydney researchers.
Ophthalmology 14 minutes ago | not rated yet | 0
The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggested that vascular endothelial ...
Ophthalmology May 17, 2013 | not rated yet | 0 |
New research is emphasizing the importance of regular screenings for glaucoma, a disease that deteriorates the optic nerve over time and is a leading cause of irreversible blindness worldwide. The onset of glaucoma is associated ...
Ophthalmology May 17, 2013 | not rated yet | 0 |
The University of Nottingham and Nottingham University Hospitals NHS Trust, have been working with Sony Computer Entertainment Europe (SCEE) to develop special 3-D glasses and games to help treat children ...
Ophthalmology May 08, 2013 | not rated yet | 0
The first successful cornea transplant with donor endothelial tissue preloaded by an eye bank has been performed at Massachusetts Eye and Ear in Boston, Mass. Roberto Pineda II, M.D., Director of the Refractive Surgery Service ...
Ophthalmology May 07, 2013 | 5 / 5 (1) | 0
(Medical Xpress)—Cardiologists have identified a trio of biomarkers that may predict which patients with heart disease have a high risk of heart attack or death in the next two years.
24 minutes ago | not rated yet | 0 |
Each day, an average of nine people are killed in the United States and more than 1,000 injured by drivers doing something other than driving.
39 minutes ago | not rated yet | 0
(Medical Xpress)—We spend about a third of our life asleep, but why we need to do so remains a mystery. In a recent publication, researchers at University of Surrey and University College London suggest a new hypothesis, ...
34 minutes ago | not rated yet | 0
(Medical Xpress)—International researchers are studying the salt intake of Indian adults to provide vital new data to aid the development of a national salt reduction strategy.
24 minutes ago | not rated yet | 0
Johns Hopkins researchers say they have discovered specific chemical alterations in two genes that, when present during pregnancy, reliably predict whether a woman will develop postpartum depression.
2 hours ago | not rated yet | 0 |
(Medical Xpress)—A three-year multinational study has tracked and detailed the progression of Huntington's disease (HD), predicting clinical decline in people carrying the HD gene more than 10 years before ...
1 hour ago | not rated yet | 0