Sumatriptan/Naproxen helpful in treating teens' migraines

Sumatriptan/Naproxen helpful in treating teens' migraines

(HealthDay) -- Treatment with sumatriptan and naproxen sodium (suma/nap) is well tolerated and effective in reducing migraine pain in adolescents, according to a study published online May 14 in Pediatrics.

Frederick J. Derosier, D.O., from in Research Triangle Park, N.C., and colleagues conducted a involving teens (aged 12 to 17 years) who had two to eight migraines per month. The first moderate-to-severe attack was treated with placebo. Those with pain two hours after dosing were randomly assigned to receive a placebo (145 patients), 10/60 mg suma/nap (96), 30/180 mg suma/nap (97), or 85/500 mg suma/nap (152) for the second attack.

The researchers found that two-hour pain-free rates (adjusted for age and baseline severity) were significantly higher with suma/nap 10/60 mg (29 percent), 30/180 mg (27 percent), and 85/500 mg (24 percent) versus placebo (10 percent) for the second attack. There were no significant differences among the three doses. For sustained pain-free two to 24 hours, two-hour photophobia-free, and two-hour phonophobia-free, there were significant differences between 85/500 mg dosing and placebo. All active doses were well tolerated.

"All doses of suma/nap were well tolerated, providing similarly effective acute treatment of adolescent migraine pain and associated symptoms, as compared with placebo," the authors conclude.

Several authors disclosed to pharmaceutical companies, including GlaxoSmithKline, which manufactures sumatriptan and sodium and funded the study.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Migraine: Aspirin and an antiemetic is a reasonable option

Apr 14, 2010

A single dose of 900-1000 mg aspirin can substantially reduce migraine headache pain within two hours, for more than half of people who take it. It also reduces any associated nausea, vomiting, and sensitivity to light or ...

Combination drug taken early relieves migraine symptoms

Jul 07, 2008

A combination drug taken within an hour after the start of a migraine is effective in relieving symptoms, according to research published in the July 8, 2008, issue of Neurology, the medical journal of the American Academ ...

ECO: New weight loss drug effective in advanced obesity

May 14, 2012

(HealthDay) -- A new combination treatment of controlled-release phentermine/topiramate (PHEN/TPM CR) leads to significantly greater weight loss than a placebo even in individuals with significant obesity-related ...

Prophylaxis with apixaban feasible for cancer patients

Mar 29, 2012

(HealthDay) -- Primary venous thromboembolism prophylaxis with apixaban, an oral direct Factor Xa inhibitor, in ambulatory cancer patients undergoing first- or second-line chemotherapy for advanced or metastatic ...

Recommended for you

Two expats die of MERS in Saudi commercial hub

14 hours ago

Two foreigners died of MERS in the Saudi city of Jeddah, the health ministry said Saturday, as fears rise over the spreading respiratory virus in the kingdom's commercial hub.

UAE reports 12 new cases of MERS

14 hours ago

Health authorities in the United Arab Emirates have announced 12 new cases of infection by the MERS coronavirus, but insisted the patients would be cured within two weeks.

Filipino tests negative for Middle East virus

Apr 19, 2014

A Filipino nurse who tested positive for the Middle East virus has been found free of infection in a subsequent examination after he returned home, Philippine health officials said Saturday.

User comments