Absolute incretin effect reduced in type 2 diabetes

June 25, 2012
Absolute incretin effect reduced in type 2 diabetes
For patients with type 2 diabetes mellitus the absolute incretin effect is reduced compared with healthy individuals, but its relative importance is increased, particularly in first-phase insulin secretion, according to a study published online June 20 in Diabetes.

(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) the absolute incretin effect is reduced compared with healthy individuals, but its relative importance is increased, particularly in first-phase insulin secretion, according to a study published online June 20 in Diabetes.

Hans Juergen Woerle, M.D., from Ludwig-Maximilians-University in Munich, Germany, and colleagues examined the role of incretins on in 12 healthy individuals and 12 patients with T2DM, using the hyperglycemic clamp technique.

The researchers found that, compared with patients with T2DM, intravenous glucose alone was associated with a significantly greater first- and second-phase insulin secretion in healthy individuals. In both groups, duodenal nutrition perfusion increased both phases of insulin secretion, with first-phase insulin secretion enhanced more in patients with T2DM (approximately eight- versus two-fold). Approximately 20 percent of the overall insulin secretion was attributable to glucose-related stimulation of insulin secretion. Infusion with the glucagon-like peptide 1 exendin(9-39) reduced both phases of insulin secretion in both groups.

"In conclusion, both phases of insulin secretion are impaired in T2DM. In particular, the responsiveness to glucose in first-phase insulin secretion is blunted," the authors write. "The absolute incretin effect is reduced in T2DM; its relative importance, however, appears to be increased, highlighting its role as an important amplifier of first-phase insulin secretion in T2DM."

Abstract

Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Promising progress for new treatment of type 1 diabetes

July 30, 2015

New research from Uppsala University shows promising progress in the use of anti-inflammatory cytokine for treatment of type 1 diabetes. The study, published in the open access journal Scientific Reports, reveals that administration ...

Bacteria may cause type 2 diabetes

June 1, 2015

Bacteria and viruses have an obvious role in causing infectious diseases, but microbes have also been identified as the surprising cause of other illnesses, including cervical cancer (Human papilloma virus) and stomach ulcers ...

'Crosstalk' gives clues to diabetes

June 15, 2015

Sometimes, listening in on a conversation can tell you a lot. For Mark Huising, an assistant professor in the Department of Neurobiology, Physiology and Behavior at the UC Davis College of Biological Sciences, that crosstalk ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.