Acellular dermal matrix safe, useful in breast reconstruction

Acellular dermal matrix safe, useful in breast reconstruction
Acellular dermal matrices provide good outcomes for patients undergoing breast reconstruction following mastectomy, but the human AlloDerm matrix has a higher seroma rate than porcine Strattice matrix, according to a study published in the June issue of Plastic and Reconstructive Surgery.

(HealthDay) -- Acellular dermal matrices provide good outcomes for patients undergoing breast reconstruction following mastectomy, but the human AlloDerm matrix has a higher seroma rate than porcine Strattice matrix, according to a study published in the June issue of Plastic and Reconstructive Surgery.

Scot B. Glasberg, M.D., and David Light, M.D., from Lenox Hill Hospital in New York City, reviewed to compare the clinical course and postoperative outcomes associated with the use of AlloDerm or Strattice acellular dermal matrices. Histologic analyses were performed on biopsy specimens of the matrices.

AlloDerm was used in 126 reconstructions in 96 patients and Strattice was used in 144 reconstructions in 90 patients. The researchers found that total complications were significantly higher with AlloDerm (21.4 versus 6.3 percent). The higher rate of complications was driven by a significantly higher seroma rate in the AlloDerm group (12.7 versus 1.4 percent). Rates of other complications were similar between the groups. The capsular contracture rate (grade 1 or 2) was 2.4 and 2.8 percent with AlloDerm and Strattice, respectively, indicating a potential role in capsule formation. This was supported by histologic analyses, which showed a lack of synovia-like metaplasia seen at the interface between the acellular dermal matrix and tissue expander.

"Complications in this series were of low severity, which, together with consistent seen in the authors' practice, justifies the cost associated with the use of acellular dermal matrices in ," the authors write.

One author disclosed to LifeCell Corporation, which provided editorial support for the study and manufactures the acellular dermal matrices.

More information: Full Text

add to favorites email to friend print save as pdf

Related Stories

Acellular dermal matrix and short bowel syndrome

Apr 28, 2010

Short bowel syndrome has puzzled surgeons for a long time and the curative effect are unsatisfactory. In recent years, acellular dermal matrix (ADM) has been used in many fields for tissue regeneration or scarless healing. ...

Rates of breast reconstruction after mastectomy in Canada

Nov 07, 2011

Few patients in Canada undergo breast reconstruction after mastectomy, despite its safety as a procedure and the positive psychological benefits, states a review article in CMAJ (Canadian Medical Association Journal).

Recommended for you

Weight-loss surgery may improve kidney function

Nov 14, 2014

In addition to helping patients shed pounds, weight loss surgery may also improve kidney function, according to a study that will be presented at ASN Kidney Week 2014 November 11-16 at the Pennsylvania Convention Center in ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.