Aspirin may not prevent blood clots that cause heart attacks and strokes among diabetics
Many patients with type 2 diabetes may be aspirin resistant. That means the standard aspirin dose may not protect them against blood clots that cause heart attacks and strokes among diabetics, a new clinical study finds. The results to be presented at The Endocrine Society's 94th Annual Meeting in Houston.
"This result adds to our understanding of the prevalence of this problem, which varies considerably among studies," said lead author Subhashini Yaturu, M.D., section chief of the Endocrinology and Metabolism Department at Stratton VA Medical Center in Albany, NY. "The standard baby aspirin may not be adequate for subjects with diabetes for cardiovascular protection."
Low doses of aspirin are recommended for the prevention of strokes and heart attacks. Aspirin is considered the usual treatment to prevent dangerous blood clots from forming. It is recommended for patients with diabetes and other high-risk medical conditions. In some cases, however, patients are resistant to aspirin's anti-clotting effects. This resistance can be identified by measuring the level of a particular chemical called 11-dehydro-thromboxane beta-2, or 11DhTx2, which is formed during the clotting process. High urinary levels of this chemical indicate resistance to aspirin and its beneficial anti-clotting effects.
The most common form of diabetes, type 2, affects nearly 11 million people age 65 and older in the United States, according to the National Diabetes Information Clearinghouse. The leading causes of death among people with this disease are heart disease and stroke.
In this clinical study, investigators found that more than half53 percentof study participants with type 2 diabetes were aspirin resistant. In addition, 11DhTx2 levels were greater among patients with a longer duration of diabetes and increased urinary levels of a particular protein, called micro albumin, an indicator of early kidney disease in diabetes. At the same time, 11DhTx2 concentrations were not associated with insulin levels, insulin resistance, or certain markers of inflammation.
High blood pressure and abdominal-fat distribution are associated with the risk of heart and blood-vessel disease. A surprising finding, according to Yaturu, was that patients with relatively higher blood-pressure readings and a greater waist circumference had lower 11DhTx2 measurements, compared to other patients.
"These results provide new information about the factors associated with aspirin resistance," Yaturu said. "This may help doctors identify people who are likely to be aspirin resistant, so that higher doses or different drugs can be prescribed to prevent blood clots. Further studies are required to clarify the appropriate dose of aspirin and or other therapies for subjects with diabetes to prevent clots. "
Participants included 142 male patients with type 2 diabetes. Their average age was 48 years, and most were Caucasian. The samples for this clinical study were collected at Overton Brooks VAMC, Shreveport, LA between 2006 and 2009 and funded by a VA Merit Review grant for a separate study entitled, "Effect of Pioglitazone on Bone density and bone markers." For the study of aspirin resistance, supplemental analyses of the samples were carried out at Stratton VAMC and Research Pharmacy Institute at Albany. The residual funds from the Merit Review grant partly supported the study.
Provided by The Endocrine Society
- Increased risk of heart attack or stroke for patients who are resistant to aspirin Jan 18, 2008 | not rated yet | 0
- Aspirin resistant proteins are identified Jun 26, 2007 | not rated yet | 0
- Aspirin enhances platelet isoprostanes in type 2 diabetes Mar 23, 2012 | not rated yet | 0
- Higher daily dose of aspirin could play key role in preventing heart attacks for those with diabetes Jul 05, 2011 | not rated yet | 0
- Aspirin may be less effective heart treatment for women than men Apr 27, 2007 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Solvability of a circuit
1 hour ago Let's say I have a circuit consisting only of a finite number of batteries and resistors, all ideal. Given an arbitrary shape of this circuit, will I...
Question about perception of colors around light sources
5 hours ago When I look at a distant light source (like car headlights, or street lamp lights) I notice colors of the visible spectrum (as separated (as in after...
Does a charged particle rotate when traveling through a static Bf?
6 hours ago I have been looking at mass spectrometers, in particular the interactions between the Bf ind of a charged particle in motion in a static Bf of the...
Find a link between physics and assignment problems
7 hours ago Hi ! I've been working about assignments problems and how to solve them. I will have to do a presentation about it in few weeks. However, I'll...
Light as a source of electricity
8 hours ago Hello Dear Fellows! We all know that light is an electromagnetic wave and also we know that an antenna receives EM waves and...
A question about the energy stored in a capacitor.
8 hours ago If we imagine a simple circuit with a battery and a capacitor with negligible internal resistance, the capacitor is charged up to a point where the...
- More from Physics Forums - Classical Physics
More news stories
(HealthDay)—Moderate aerobic exercise prevents fructose-induced hypertriglyceridemia in healthy males, according to a study published online May 14 in Diabetes.
Diabetes May 17, 2013 | 5 / 5 (1) | 0 |
A DNA variant near a digestive enzyme does not only affect risk of developing diabetes but also affects the response to treatment, an international consortium of researchers including the University of Dundee has found.
Diabetes May 17, 2013 | not rated yet | 0 |
(Medical Xpress)—Development of a sophisticated artificial pancreas holds potential to transform the lives of patients with Type 1 diabetes.
Diabetes May 16, 2013 | 5 / 5 (1) | 0 |
A small University at Buffalo study has found for the first time that in Type 1 diabetics, insulin injections exert a strong anti-inflammatory effect at the cellular and molecular level, while even small amounts of glucose ...
Diabetes May 16, 2013 | not rated yet | 0
(HealthDay)—Home diabetes regimens partially explain the increased risk of having a hypoglycemia event during hospitalization among older African-American men with diabetes, according to a study published ...
Diabetes May 14, 2013 | not rated yet | 0
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
7 hours ago | not rated yet | 0 |
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
8 hours ago | 5 / 5 (2) | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
7 hours ago | 5 / 5 (1) | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
8 hours ago | 5 / 5 (3) | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
12 hours ago | not rated yet | 0
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
7 hours ago | not rated yet | 0