Researchers confirm breast cancer regulator also found in prostate cancer

June 1, 2012

Researchers at Clarkson University in Potsdam, N.Y., led by Chemistry & Biomolecular Science Professor Costel C. Darie, in collaboration with researchers from Columbia University, have now found the binding partner of TDF, a pituitary hormone that had previously been shown to reduce cancer progression in breast cancer cells, in prostate cancer as well.

The study suggests that TDF may play a general role of inhibiting cancerous cells in both the breast and in the prostate.

"Finding the receptor for the TDF hormone in both the breast and prostate will allow us to design treatments targeting both cancer types," said Darie.

Darie's group has led in the search for a cellular receptor in cancer cells that might bind TDF and inhibit tumor growth. A receptor, labeled TDF-R, was found exclusively in the prostate and breast, but not in other , suggesting that this factor is specific to these cancer types.

The results of the research will be reported in an upcoming issue of a journal published by the Federation of European Biochemical Societies (FEBS).

Most of the research work was performed by Izabela Sokolowska, a Ph.D. student in Darie's lab.

The work was supported in part by the U.S. Army Research Laboratory's Army Research Office (ARO) through the Defense University Research Instrumentation Program (DURIP grant #W911NF-11-1-0304) and the Keep A Breast Foundation (KEABF-375-35054).

According to the American Cancer Society about 241,740 new cases of prostate cancer will be diagnosed in 2012, approximately 28,170 men will die of prostate cancer and approximately one man in six will be diagnosed with in his life.

Related Stories

Breast cancer type linked to paternal cancer

November 28, 2011

The risk of breast cancer is increased by genetic and lifestyle factors such as the inherited BRCA2 gene, age of having first child, or use of hormone replacement therapy (HRT). New research published in BioMed Central's ...

Study identifies new prostate cancer drug target

February 6, 2012

Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published ...

Recommended for you

Study reveals new insight into DNA repair

August 3, 2015

DNA double-strand breaks (DSBs) are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy. New information published this week reveals more about why this occurs and how these breaks ...

Strange circular DNA may offer new way to detect cancers

July 30, 2015

Strange rings of DNA that exist outside chromosomes are distinct to the cell types that mistakenly produced them, researchers have discovered. The finding raises the tantalizing possibility that the rings could be used as ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.