Depression linked to reduced temporofrontolimbic coupling

Depression linked to reduced temporofrontolimbic coupling

(HealthDay) -- Patients with remitted major depressive disorder (MDD) have reduced guilt-selective temporofrontolimbic coupling between the right superior anterior temporal lobe (ATL) and subgenual cingulate cortex and adjacent septal region (SCSR), a region of interest for biases toward guilt versus indignation, according to a study published online June 4 in the Archives of General Psychiatry.

Sophie Green, Ph.D., from the University of Manchester in the United Kingdom, and colleagues used to investigate whether individuals with MDD exhibit guilt-selective SCSR-ATL decoupling. Participants included 25 patients with remitted MDD and 22 controls with no personal or family history of MDD.

The researchers identified a guilt-selective decrease in ATL-SCSR coupling in patients with MDD, compared with controls. In addition, while controlling for medication status and intensity of , there was decoupling seen with medial frontopolar, right hippocampal, and lateral hypothalamic areas. Lower levels of ATL-SCSR coupling correlated with elevated scores on the 67-item Interpersonal Guilt Questionnaire, a validated measure of overgeneralized self-blame.

"We demonstrated a guilt-selective decrease in ATL coupling in remitted MDD across a frontolimbic network of the SCSR, medial frontopolar cortex, lateral hypothalamus, and hippocampus," the authors write. "These results shed new light on the pathophysiology of vulnerability to MDD by providing a specific neural mechanism that can account for self-blaming biases long known to be a core and distinctive feature of MDD."

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Study: Many physicians not using established criteria

Feb 02, 2010

A new study led by Mark Zimmerman, MD, of Rhode Island Hospital indicates that a majority of non-psychiatrist physicians and a substantial minority of psychiatrists reported that they often do not use the criteria outlined ...

Researchers build a better mouse model to study depression

May 19, 2011

Researchers at the University of Pittsburgh School of Medicine have developed a mouse model of major depressive disorder (MDD) that is based on a rare genetic mutation that appears to cause MDD in the majority of people who ...

Recommended for you

Report advocates improved police training

Aug 29, 2014

A new report released yesterday by the Mental Health Commission of Canada identifies ways to improve the mental health training and education that police personnel receive.

Meaningful relationships can help you thrive

Aug 29, 2014

Deep and meaningful relationships play a vital role in overall well-being. Past research has shown that individuals with supportive and rewarding relationships have better mental health, higher levels of subjective well-being ...

Learning to read involves tricking the brain

Aug 29, 2014

While reading, children and adults alike must avoid confusing mirror-image letters (like b/d or p/q). Why is it difficult to differentiate these letters? When learning to read, our brain must be able to inhibit ...

User comments