Depression linked to reduced temporofrontolimbic coupling

June 6, 2012
Depression linked to reduced temporofrontolimbic coupling

(HealthDay) -- Patients with remitted major depressive disorder (MDD) have reduced guilt-selective temporofrontolimbic coupling between the right superior anterior temporal lobe (ATL) and subgenual cingulate cortex and adjacent septal region (SCSR), a region of interest for biases toward guilt versus indignation, according to a study published online June 4 in the Archives of General Psychiatry.

Sophie Green, Ph.D., from the University of Manchester in the United Kingdom, and colleagues used to investigate whether individuals with MDD exhibit guilt-selective SCSR-ATL decoupling. Participants included 25 patients with remitted MDD and 22 controls with no personal or family history of MDD.

The researchers identified a guilt-selective decrease in ATL-SCSR coupling in patients with MDD, compared with controls. In addition, while controlling for medication status and intensity of , there was decoupling seen with medial frontopolar, right hippocampal, and lateral hypothalamic areas. Lower levels of ATL-SCSR coupling correlated with elevated scores on the 67-item Interpersonal Guilt Questionnaire, a validated measure of overgeneralized self-blame.

"We demonstrated a guilt-selective decrease in ATL coupling in remitted MDD across a frontolimbic network of the SCSR, medial frontopolar cortex, lateral hypothalamus, and hippocampus," the authors write. "These results shed new light on the pathophysiology of vulnerability to MDD by providing a specific neural mechanism that can account for self-blaming biases long known to be a core and distinctive feature of MDD."

Explore further: Brain scans prove Freud right: Guilt plays key role in depression

More information: Abstract
Full Text

Related Stories

Recommended for you

How we handle objects depends on who owns them

September 27, 2016

From scissors and staplers to car keys and cell phones, we pass objects to other people every day. We often try to pass the objects so that the handle or other useful feature is facing the appropriate direction for the person ...

Dogs ignore bad advice that humans follow

September 27, 2016

Dogs are less likely to follow bad advice than children, according to a new study conducted at the Canine Cognition Center at Yale. In contrast to children, dogs only copy a human's actions if they are absolutely necessary ...

The birth of politics in children—the case of dominance

September 26, 2016

As they grow up, do children become young Robin Hoods? Depending on their age, they do not allocate resources in the same way between dominant and subordinate individuals. Thus a tendency towards egalitarianism develops and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.