Depression linked to reduced temporofrontolimbic coupling
(HealthDay) -- Patients with remitted major depressive disorder (MDD) have reduced guilt-selective temporofrontolimbic coupling between the right superior anterior temporal lobe (ATL) and subgenual cingulate cortex and adjacent septal region (SCSR), a region of interest for biases toward guilt versus indignation, according to a study published online June 4 in the Archives of General Psychiatry.
Sophie Green, Ph.D., from the University of Manchester in the United Kingdom, and colleagues used functional magnetic resonance imaging to investigate whether individuals with MDD exhibit guilt-selective SCSR-ATL decoupling. Participants included 25 patients with remitted MDD and 22 controls with no personal or family history of MDD.
The researchers identified a guilt-selective decrease in ATL-SCSR coupling in patients with MDD, compared with controls. In addition, while controlling for medication status and intensity of negative emotions, there was decoupling seen with medial frontopolar, right hippocampal, and lateral hypothalamic areas. Lower levels of ATL-SCSR coupling correlated with elevated scores on the 67-item Interpersonal Guilt Questionnaire, a validated measure of overgeneralized self-blame.
"We demonstrated a guilt-selective decrease in ATL coupling in remitted MDD across a frontolimbic network of the SCSR, medial frontopolar cortex, lateral hypothalamus, and hippocampus," the authors write. "These results shed new light on the pathophysiology of vulnerability to MDD by providing a specific neural mechanism that can account for self-blaming biases long known to be a core and distinctive feature of MDD."
Journal reference: JAMA Psychiatry
Copyright © 2012 HealthDay. All rights reserved.
- Researchers find new way to examine major depressive disorder in children May 10, 2011 | not rated yet | 0
- Study: Many physicians not using established criteria Feb 02, 2010 | not rated yet | 0
- Study finds high prevalence of depression after traumatic brain injury May 18, 2010 | not rated yet | 0
- Researchers build a better mouse model to study depression May 19, 2011 | not rated yet | 0
- Brain scans prove Freud right: Guilt plays key role in depression Jun 04, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
Patients with treatment-resistant major depression saw dramatic improvement in their illness after treatment with ketamine, an anesthetic, according to the largest ketamine clinical trial to-date led by researchers from the ...
Psychology & Psychiatry 13 hours ago | 4.7 / 5 (3) | 0 |
The latest makeover to a massive psychiatric tome honored by some, reviled by others and even called the "Bible" of mental disorders is being released Saturday with a host of new changes.
Psychology & Psychiatry May 18, 2013 | not rated yet | 1
(HealthDay)—Most Medicare beneficiaries treated in inpatient psychiatric facilities (IPFs) exhibit characteristics associated with hospital readmission, according to a report prepared for the National Association ...
Psychology & Psychiatry May 17, 2013 | not rated yet | 0
Skydivers show the same level of physical stress before every jump whether a first-timer or experienced jumper, say Northumbria researchers.
Psychology & Psychiatry May 17, 2013 | not rated yet | 0 |
Children of depressed parents pick up on their parents' sadness—whether mom or dad realizes their mood or not.
Psychology & Psychiatry May 17, 2013 | 4.5 / 5 (2) | 1 |
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
51 minutes ago | not rated yet | 0 |
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
51 minutes ago | not rated yet | 0
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
1 hour ago | not rated yet | 0 |
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
1 hour ago | 5 / 5 (1) | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
1 hour ago | 5 / 5 (1) | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
5 hours ago | not rated yet | 0