Early loss of glucagon response to hypoglycemia found in teens

June 22, 2012
Early loss of glucagon response to hypoglycemia found in teens
In adolescents with type 1 diabetes the glucagon response to hypoglycemia is lost as early as one month and at a median of eight months after diabetes diagnosis, according to a study published online June 14 in Diabetes Care.

(HealthDay) -- In adolescents with type 1 diabetes the glucagon response to hypoglycemia is lost as early as one month and at a median of eight months after diabetes diagnosis, according to a study published online June 14 in Diabetes Care.

To investigate the glucagon response to hypoglycemia in adolescents with type 1 diabetes, Aris Siafarikas, M.D., of the Princess Margaret Hospital for Children in Perth, Australia, and colleagues conducted a study involving 28 nonobese adolescents with type 1 diabetes (median duration, 0.66 years) and 12 healthy control subjects.

The researchers found that there was a similar glucagon peak to arginine stimulation between the groups (P = 0.27). In adolescents with type 1 diabetes the glucagon peak to hypoglycemia was statistically significantly lower than in control individuals (68 versus 96 pg/mL). For 7 percent of adolescents with diabetes and 83 percent of controls this response was more than three standard deviations greater from baseline and was lost after a median duration of eight months of diabetes and as early as one month after diagnosis. The response did not correlate with height, weight, , or glycated hemoglobin.

"We conclude that adolescents with type 1 diabetes have impaired glucagon responses to hypoglycemia within 12 months of diagnosis," the authors write. "Prospective studies in children and adolescents starting from the onset of are needed to further characterize the mechanisms influencing the change over time in the response to hypoglycemia."

Explore further: Diet soda linked to increase in glucagon-like peptide 1 levels

More information: Abstract
Full Text (subscription or payment may be required)


Related Stories

Study assesses glucose monitoring trends in tweens

April 12, 2012

(HealthDay) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published online April ...

Recommended for you

Gut bacteria imbalance increases diabetes risk

July 13, 2016

Currently, scientists think the major contributors to insulin resistance are excess weight and physical inactivity, yet ground-breaking new research by an EU funded European-Chinese team of investigators called MetaHit have ...

Which diabetes drug is best?

July 19, 2016

(HealthDay)—No single drug to treat type 2 diabetes stands out from the pack when it comes to reducing the risks of heart disease, stroke or premature death, a new research review finds.

Team explores genetic architecture of type 2 diabetes

July 11, 2016

New research from a large international team of scientists offers a more complete picture of the genes responsible for type 2 diabetes, demonstrating that previously identified common alleles shared by many in the world are ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.