Early loss of glucagon response to hypoglycemia found in teens

Early loss of glucagon response to hypoglycemia found in teens
In adolescents with type 1 diabetes the glucagon response to hypoglycemia is lost as early as one month and at a median of eight months after diabetes diagnosis, according to a study published online June 14 in Diabetes Care.

(HealthDay) -- In adolescents with type 1 diabetes the glucagon response to hypoglycemia is lost as early as one month and at a median of eight months after diabetes diagnosis, according to a study published online June 14 in Diabetes Care.

To investigate the glucagon response to hypoglycemia in adolescents with type 1 diabetes, Aris Siafarikas, M.D., of the Princess Margaret Hospital for Children in Perth, Australia, and colleagues conducted a study involving 28 nonobese adolescents with type 1 diabetes (median duration, 0.66 years) and 12 healthy control subjects.

The researchers found that there was a similar glucagon peak to arginine stimulation between the groups (P = 0.27). In adolescents with type 1 diabetes the glucagon peak to hypoglycemia was statistically significantly lower than in control individuals (68 versus 96 pg/mL). For 7 percent of adolescents with diabetes and 83 percent of controls this response was more than three standard deviations greater from baseline and was lost after a median duration of eight months of diabetes and as early as one month after diagnosis. The response did not correlate with height, weight, , or glycated hemoglobin.

"We conclude that adolescents with type 1 diabetes have impaired glucagon responses to hypoglycemia within 12 months of diagnosis," the authors write. "Prospective studies in children and adolescents starting from the onset of are needed to further characterize the mechanisms influencing the change over time in the response to hypoglycemia."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Study pinpoints role of insulin on glucagon levels

Apr 07, 2009

April 7, 2009 - Researchers at the Joslin Diabetes Center have shown for the first time that insulin plays a key role in suppressing levels of glucagon, a hormone involved in carbohydrate metabolism and regulating blood glucose ...

Recommended for you

Blood glucose levels set for achieving HbA1c targets

Apr 11, 2014

(HealthDay)—The average self-monitored blood glucose (SMBG) concentrations needed at premeal, postmeal, and bedtime have been established to achieve a range of hemoglobin A1c (HbA1c) targets, according ...

Women with diabetes less likely to have a mammogram

Apr 11, 2014

Women with diabetes are 14 per cent less likely to be screened for breast cancer compared to women without diabetes, according to a study by researchers at the Institute for Clinical Evaluative Sciences (ICES) and Women's ...

User comments