Factors ID'd in healing failure of diabetic foot ulcers

June 15, 2012

(HealthDay) -- Patients with diabetes whose foot ulcers fail to heal have increased inflammation and aberrant growth factor levels, according to a study published online June 11 in Diabetes.

Thanh Dinh, D.P.M., from the Beth Israel Deaconess Medical Center in Boston, and colleagues followed 104 patients with type 1 or 2 diabetes and 36 healthy controls to investigate whether vascular function and inflammation play a role in the development and healing of .

The researchers found that, after a mean of 18.4 months, 30 patients with diabetes (29 percent) developed foot ulcers. These patients had more severe neuropathy, a higher white , and reduced vasodilation. Ulcers failed to heal in 47 percent of these patients. Compared with those who healed, these patients had higher serum levels of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, matrix metallopeptidase 9 (MMP-9), and fibroblast growth factor 2. Compared with skin samples from control patients, patients with diabetes had greater immune cell infiltration, MMP-9 expression, and protein tyrosine phosphatase-1B (PTP1B).

"We conclude that increased inflammation, expression of MMP-9, PTP1B, and aberrant growth factor levels are the main factors associated with failure to heal diabetic foot ulcers," Dinh and colleagues write.

Explore further: Gene profile correlates with glycemia in type 1 diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Gene profile correlates with glycemia in type 1 diabetes

March 16, 2012

(HealthDay) -- A gene expression profile in peripheral blood correlates with glycemic control in the first year for patients recently diagnosed with type 1 diabetes, according to a study published online March 8 in Diabetes.

Recommended for you

How does friendly fire happen in the pancreas?

October 21, 2016

In type 1 diabetes, the body attacks its own insulin-producing cells. Scientists at Helmholtz Zentrum München, partner in the German Center for Diabetes Research, and their colleagues at Technical University of Munich have ...

Diabetes opens floodgates to fructose

October 11, 2016

Fructose, once seen as diabetics' alternative to glucose, is fast-tracked to the liver in diabetic mice and contributes to metabolic diseases, according to new research from Harvard University.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.