Risk factors ID'd for SCA in heart defect repair survivors

Risk factors ID'd for SCA in heart defect repair survivors
In adult survivors of surgery for congenital heart disease, severe subaortic ventricular systolic dysfunction is a significant and independent predictor of sudden cardiac arrest, according to research published in the July 1 issue of The American Journal of Cardiology.

(HealthDay) -- In adult survivors of surgery for congenital heart disease (CHD), severe subaortic ventricular systolic dysfunction is a significant and independent predictor of sudden cardiac arrest (SCA), according to research published in the July 1 issue of The American Journal of Cardiology.

Pastora Gallego, M.D., Ph.D., of the La Paz University Hospital in Madrid, and colleagues conducted a longitudinal cohort study involving 936 adults (mean age at first examination, 21 years) with previously repaired CHD who had been followed up at a tertiary care facility for a mean period of nine years. included tetralogy of Fallot, coarctation of the aorta, transposition complexes, and single ventricle.

During 8,387 person-years of follow-up the researchers found that 22 patients presented with SCA (2.6 per 1,000 person-years). Independent risk factors for SCA were age at initial examination and severely impaired subaortic ventricular systolic function (adjusted hazard ratios, 1.05 and 29, respectively). SCA occurred in 0.7 percent of patients with non-severe decreased subaortic ventricular function and in 23 percent of those with severe subaortic ventricular systolic dysfunction (P < 0.001).

"To our knowledge, this is the first longitudinal cohort study to analyze predictors of SCA in a large population of adult survivors after operation for CHD at <20 years of age," the authors write. "Results indicated that severe systemic ventricular dysfunction has an outstanding role as a dominant multivariate predictor of SCA for all combined diagnoses in this heterogeneous population."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

QRS width on ECG linked to sudden cardiac arrest in CAD

Apr 20, 2012

(HealthDay) -- For patients with coronary artery disease (CAD), QRS width on electrocardiogram and echocardiographic evidence of heart failure are associated with out-of-hospital sudden cardiac arrest (SCA), ...

Recommended for you

Poor response to cholesterol drugs may indicate blocked arteries

Feb 26, 2015

If your "bad" cholesterol level stays the same or increases after you take statin drugs, you may have more blocked arteries than people whose levels drop, according to research in the American Heart Association journal Arteriosclerosis, Th ...

Review: more whole grains, less coronary heart disease

Feb 25, 2015

(HealthDay)—Higher dietary intake of whole grains may reduce the risk of coronary heart disease (CHD), according to a meta-analysis published in the March 1 issue of The American Journal of Cardiology.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.