Intranasal insulin linked to reduced food intake

Intranasal insulin linked to reduced food intake
Intranasally administered insulin is associated with higher brain energy levels and reduced calorie intake, according to a study published online May 14 in Diabetes.

(HealthDay) -- Intranasally administered insulin is associated with higher brain energy levels and reduced calorie intake, according to a study published online May 14 in Diabetes.

To examine whether intranasal insulin reduced food consumption by increasing neuroenergetic levels, Kamila Jauch-Chara, M.D., from the University of Luebeck in Germany, and colleagues intranasally administered insulin (40 IU) or a placebo (within subject comparison) to 15 young (22 to 28 years of age), healthy, normal-weight men after an overnight fast and then measured cerebral energy metabolism by . At 100 minutes after treatment, the men were allowed to eat freely from a test buffet.

The researchers found that intranasal insulin increased , as determined by increased adenosine triphosphate and phosphocreatine levels, which was associated with a reduction in subsequent free-choice . The authors note that, consistent with this, their previous study showed that higher cerebral energy content was associated with lower .

"Brain energy levels may therefore constitute a predictive value for food intake," Jauch-Chara and colleagues conclude. "Given that the brain synchronizes food intake behavior in dependence of its current energetic status, a future challenge in obesity treatment may be to therapeutically influence cerebral energy homeostasis."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

The metabolic effects of antipsychotic drugs

Jul 12, 2011

Research to be presented at the upcoming annual meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, may explain why some antipsychotic ...

Insulin may influence body weight gain in former smokers

May 09, 2012

It is probably safe to say that smokers refuse to give up their vice because they believe their waistlines will only get bigger. And while most researchers have long speculated that a metabolic link exists ...

Improving obesity-induced insulin sensitivity

Jun 01, 2012

In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into ...

Recommended for you

Magnesium cuts diabetes risk

10 hours ago

Getting enough magnesium in the diet may reduce the risk of diabetes, especially for those who already show signs of heading that way.

Personalised treatment for stress-related diabetes

Oct 14, 2014

Researchers at Lund University in Sweden are testing a treatment for type 2 diabetes which targets the disease mechanism itself - and not just the symptoms. For the first time, knowledge about the individual patient's genetic ...

Sensors to simplify diabetes management

Oct 13, 2014

For many patients diagnosed with diabetes, treating the disease can mean a burdensome and uncomfortable lifelong routine of monitoring blood sugar levels and injecting the insulin that their bodies don't ...

User comments