Marker helps predict thrombotic risk of hormonal contraceptives

June 8, 2012
Marker helps predict thrombotic risk of hormonal contraceptives
For women taking hormonal contraceptives, sex hormone-binding globulin is a useful marker to estimate the risk of venous thrombosis, according to research published in the June issue of the Journal of Thrombosis and Haemostasis.

(HealthDay) -- For women taking hormonal contraceptives, sex hormone-binding globulin (SHBG) is a useful marker to estimate the risk of venous thrombosis, according to research published in the June issue of the Journal of Thrombosis and Haemostasis.

To assess whether SHBG is useful as a marker for thrombotic risk, Marjolein Raps, M.D., of the Leiden University Medical Center in the Netherlands, and colleagues conducted an observational study involving 262 users of different contraceptives. SHBG levels were measured and compared with normalized activated protein C sensitivity ratio (nAPCsr) values and thrombosis risks reported in the literature.

The researchers found that, compared with users of combined contraceptives containing , which have a lower thrombosis risk, higher SHBG levels were seen in women taking containing desogestrel, cyproterone acetate, or , or using a transdermal patch, all of which carry a higher risk of venous thrombosis. SHBG levels were highest in users of the patch. SHBG levels correlated positively with both the nAPCsr and with thrombosis risks reported in recent literature.

"In conclusion, our data support the idea that SHBG could be a useful marker for estimating the risk of venous thrombosis of a new hormonal contraceptive," the authors write. "Preferably, the effect of a new hormonal contraceptive on SHBG should be compared with the effect of the combined hormonal contraceptive with the lowest reported risk of venous ."

More information: Abstract
Full Text (subscription or payment may be required)


Related Stories

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.