Metabolic syndrome linked to arterial stiffness in CKD

June 4, 2012
Metabolic syndrome linked to arterial stiffness in CKD

(HealthDay) -- For patients with chronic kidney disease (CKD), those with metabolic syndrome (MetS) have increased arterial stiffness but no increase in endothelial dysfunction, compared to those without MetS, according to a study published online May 29 in Diabetes Care.

Pajaree Lilitkarntakul, M.D., from the University of Edinburgh in the United Kingdom, and colleagues assessed carotid-femoral pulse wave velocity (CF-PWV) and flow-mediated dilation (FMD) as measures of arterial stiffness and endothelial dysfunction, respectively, in 113 minimally comorbid CKD patients and 23 matched controls.

The researchers found that there were significant associations for systolic blood pressure (SBP), waist circumference, and with CF-PWV (r², 0.25, 0.09, and 0.09, respectively). FMD was significantly associated with both SBP and waist circumference (r², 0.09 and 0.03, respectively). As the number of risk factors for MetS increased, CF-PWV increased progressively (r² = 0.07). Independent determinants for CF-PWV were SBP and , but only SBP predicted FMD.

"CKD patients with MetS have increased arterial stiffness compared with those without MetS but no difference in endothelial function," the authors write. "Although blood pressure remains the strongest determinant of both arterial stiffness and , the presence of MetS or its risk factors is also an important determinant of arterial stiffness in this CKD cohort."

Explore further: A novel method for simultaneously measuring blood pressure and arterial stiffness

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

How does friendly fire happen in the pancreas?

October 21, 2016

In type 1 diabetes, the body attacks its own insulin-producing cells. Scientists at Helmholtz Zentrum München, partner in the German Center for Diabetes Research, and their colleagues at Technical University of Munich have ...

Diabetes opens floodgates to fructose

October 11, 2016

Fructose, once seen as diabetics' alternative to glucose, is fast-tracked to the liver in diabetic mice and contributes to metabolic diseases, according to new research from Harvard University.

Type 2 diabetes and obesity—what do we really know?

October 6, 2016

Social and economic factors have led to a dramatic rise in type 2 diabetes and obesity around the world. In a review in Science, Mark McCarthy, professor at the University of Oxford, UK, and Paul Franks, professor at Lund ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.