Metabolic syndrome linked to arterial stiffness in CKD

Metabolic syndrome linked to arterial stiffness in CKD

(HealthDay) -- For patients with chronic kidney disease (CKD), those with metabolic syndrome (MetS) have increased arterial stiffness but no increase in endothelial dysfunction, compared to those without MetS, according to a study published online May 29 in Diabetes Care.

Pajaree Lilitkarntakul, M.D., from the University of Edinburgh in the United Kingdom, and colleagues assessed carotid-femoral pulse wave velocity (CF-PWV) and flow-mediated dilation (FMD) as measures of arterial stiffness and endothelial dysfunction, respectively, in 113 minimally comorbid CKD patients and 23 matched controls.

The researchers found that there were significant associations for systolic blood pressure (SBP), waist circumference, and with CF-PWV (r², 0.25, 0.09, and 0.09, respectively). FMD was significantly associated with both SBP and waist circumference (r², 0.09 and 0.03, respectively). As the number of risk factors for MetS increased, CF-PWV increased progressively (r² = 0.07). Independent determinants for CF-PWV were SBP and , but only SBP predicted FMD.

"CKD patients with MetS have increased arterial stiffness compared with those without MetS but no difference in endothelial function," the authors write. "Although blood pressure remains the strongest determinant of both arterial stiffness and , the presence of MetS or its risk factors is also an important determinant of arterial stiffness in this CKD cohort."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Moderate exercise cuts rate of metabolic syndrome

Dec 17, 2007

Research from Duke University Medical Center shows that even a modest amount of brisk walking weekly is enough to trim waistlines and cut the risk of metabolic syndrome (MetS), an increasingly frequent condition linked to ...

Recommended for you

Scientist finds clearer obesity, diabetes connection

5 hours ago

(Medical Xpress)—New findings about the biological links between obesity and insulin resistance and Type 2 diabetes may also shed light on the connection between obesity and cancer, says a scientist at ...

New test helps diagnose type 1 diabetes

Aug 21, 2014

(HealthDay)—The U.S. Food and Drug Administration has approved a new test that may help doctors diagnose type 1 diabetes, the most common form diagnosed in children and adolescents.

User comments