Improving obesity-induced insulin sensitivity

June 1, 2012

In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into other tissues. Obesity is a major factor that contributes to insulin resistance, which can eventually lead to type 2 diabetes. Previous studies have shown that proinflammatory molecules found in fat tissue decreases sensitivity of tissues to insulin.

To identify drug targets that will improve insulin sensitivity, Dr. Jerrold Olefsky and colleagues from the University of California in San Diego investigated the role of G protein-coupled receptor 21 (GPR21) in insulin resistance and energy homeostasis. The group compared mice without the gene encoding GPR21 to healthy control mice under normal and high-fat diet conditions. They discovered that mice lacking GPR21 had enhanced insulin sensitivity and increased energy expenditure independent of diet.

This result was attributed to the reduced migration of inflammatory cells to the liver and fat tissue in the absence GPR21. Under normal diet, absence of GPR21 in the hypothalamus caused a modest decrease in body weight. This is the first study to demonstrate the negative impact of GPR21 on inflammation and . Their findings suggest that GPR21 inhibition may improve and enhance energy expenditure, making GPR21 inhibitors promising treatments for diabetes.

Explore further: Study has shown to reverse obesity, body fat and improve insulin sensitivity in mice

More information: G protein–coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice, Journal of Clinical Investigation, 2012.

Related Stories

Recommended for you

Now is the lightest you will weigh all year

September 28, 2016

As swimsuit season wanes and the holiday season edges closer, Americans everywhere should take a moment to enjoy the current state of their waistline. For the average person, the time just before the start of the holiday ...

Study reveals a biological link between stress and obesity

September 21, 2016

Metabolic and anxiety-related disorders both pose a significant healthcare burden, and are in the spotlight of contemporary research and therapeutic efforts. Although intuitively we assume that these two phenomena overlap, ...

A metabolic master switch underlying human obesity

August 19, 2015

Obesity is one of the biggest public health challenges of the 21st century. Affecting more than 500 million people worldwide, obesity costs at least $200 billion each year in the United States alone, and contributes to potentially ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.