Improving obesity-induced insulin sensitivity

June 1, 2012

In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into other tissues. Obesity is a major factor that contributes to insulin resistance, which can eventually lead to type 2 diabetes. Previous studies have shown that proinflammatory molecules found in fat tissue decreases sensitivity of tissues to insulin.

To identify drug targets that will improve insulin sensitivity, Dr. Jerrold Olefsky and colleagues from the University of California in San Diego investigated the role of G protein-coupled receptor 21 (GPR21) in insulin resistance and energy homeostasis. The group compared mice without the gene encoding GPR21 to healthy control mice under normal and high-fat diet conditions. They discovered that mice lacking GPR21 had enhanced insulin sensitivity and increased energy expenditure independent of diet.

This result was attributed to the reduced migration of inflammatory cells to the liver and fat tissue in the absence GPR21. Under normal diet, absence of GPR21 in the hypothalamus caused a modest decrease in body weight. This is the first study to demonstrate the negative impact of GPR21 on inflammation and . Their findings suggest that GPR21 inhibition may improve and enhance energy expenditure, making GPR21 inhibitors promising treatments for diabetes.

Explore further: Study has shown to reverse obesity, body fat and improve insulin sensitivity in mice

More information: G protein–coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice, Journal of Clinical Investigation, 2012.

Related Stories

Tale of 2 mice pinpoints major factor for insulin resistance

May 16, 2011

The road to type 2 diabetes is paved with insulin resistance, a condition often associated with obesity in which the hormone begins to fail at its job helping to convert sugars to energy. Researchers at Joslin Diabetes Center ...

Recommended for you

Yo-yo dieting might cause extra weight gain

December 5, 2016

Repeated dieting may lead to weight gain because the brain interprets the diets as short famines and urges the person to store more fat for future shortages, new research by the universities of Exeter and Bristol suggests.

New target receptor discovered in the fight against obesity

November 25, 2016

The team of scientists from King's College London and Imperial College London tested a high-fat diet, containing a fermentable carbohydrate, and a control diet on mice and looked at the effect on food intake of those with ...

Does where you live affect what you weigh?

November 21, 2016

Adult obesity rates in the United States have reached epidemic proportions, with one in four people considered obese. Yet, obesity rates vary considerably across states and counties.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.