Overweight men can boost low testosterone levels by losing weight

June 25, 2012

Weight loss can reduce the prevalence of low testosterone levels in overweight, middle-aged men with prediabetes by almost 50 percent, a new study finds. Results will be presented Monday at The Endocrine Society's 94th Annual Meeting in Houston.

"Doctors should first encourage overweight men with low to try to lose weight through diet and exercise before resorting to testosterone therapy to raise their hormone levels," said study co-author Frances Hayes, MD, professor at St. Vincent's University Hospital, Dublin.

The new study involved nearly 900 men with (also called impaired ) who had participated in the Diabetes Prevention Program. That now-completed U.S. study showed that people at high risk of could delay or avoid developing the disease through weight loss. Because overweight men are more likely to have low testosterone levels, Hayes and her colleagues studied the effect of on men's testosterone levels.

The investigators excluded men from the study who had a known diagnosis of hypogonadism or were taking medications that could interfere with testosterone levels. Hypogonadism is a condition characterized by low testosterone levels with symptoms of male hormone deficiency. Symptoms can include reduced sex drive, poor erections, enlarged breasts and low sperm counts.

The study population had 891 middle-aged men, with an average age of 54 years. The men were randomly assigned to receive one of three treatments: 293 men to lifestyle modification, 305 to the metformin and 293 to inactive placebo pills. Lifestyle modifications consisted of exercising for 150 minutes a week and eating less fat and fewer calories.

The results showed that low testosterone levels are common in overweight men with prediabetes, Hayes said. At the beginning of the study, nearly one in four men had low testosterone levels, considered to be below 300 nanograms per deciliter.

With lifestyle modification, the prevalence of decreased from about 20 percent to 11 percent after one year, a 46 percent decrease, the authors reported. The prevalence of low testosterone was unchanged in the metformin group (24.8 versus 23.8 percent) and the placebo group (25.6 versus 24.6 percent).

Men in the lifestyle modification group lost an average of about 17 pounds (7.8 kilograms) over the one-year study, according to the abstract. The increase in testosterone levels in that group correlated with decreasing body weight and waist size.

"Losing weight not only reduces the risk of prediabetic men progressing to diabetes but also appears to increase their body's production of testosterone," Hayes said.

Explore further: Surgery-related weight loss in men reverses testosterone deficiency

Related Stories

Recommended for you

A metabolic master switch underlying human obesity

August 19, 2015

Obesity is one of the biggest public health challenges of the 21st century. Affecting more than 500 million people worldwide, obesity costs at least $200 billion each year in the United States alone, and contributes to potentially ...

Scientists probe obesity's ties to breast cancer risk

August 20, 2015

Obesity is a well-known risk factor for breast cancer, but researchers haven't figured out what connects the two. A new study suggests the link may be due to a change in breast tissue structure, which might promote breast ...

Can a new drug brown the fat and trim the obese person?

May 28, 2015

New research has found that a variant of a drug used to treat pulmonary arterial hypertension prompts weight loss in obese mice. Among mice fed a high-fat diet, those who did not get the medication became obese while medicated ...

Changing stem cell structure may help fight obesity

February 17, 2015

The research, conducted at Queen Mary University of London (QMUL), found that a slight regulation in the length of primary cilia, small hair-like projections found on most cells, prevented the production of fat cells from ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.