Many patients keep using PPIs after negative GERD test

Many patients keep using PPIs after negative GERD test
Nearly half of patients continue to use proton pump inhibitors (PPIs) even after pH studies confirm that they do not have gastroesophageal reflux disease, and most do not recall being instructed to stop taking PPIs, according to a study published in the June issue of Clinical Gastroenterology and Hepatology.

(HealthDay) -- Nearly half of patients continue to use proton pump inhibitors (PPIs) even after pH studies confirm that they do not have gastroesophageal reflux disease (GERD), and most do not recall being instructed to stop taking PPIs, according to a study published in the June issue of Clinical Gastroenterology and Hepatology.

Andrew J. Gawron, M.D., of the Feinberg School of Medicine at Northwestern University in Chicago, and colleagues conducted a retrospective study involving 90 patients who had undergone Bravo pH monitoring or multichannel intraluminal impedance-pH testing without evidence of GERD. Patients were compared by current use of PPIs.

The researchers found that 42.2 percent of patients continued to use PPIs despite a negative pH study result. Only 18.9 percent of patients remembered being instructed to stop taking PPIs. A chart review revealed documented instructions to stop PPI therapy in 16.7 percent of patients. Although no significant demographic or clinical differences were observed among patients currently taking PPIs or not, patients who continued to take a PPI were more likely to report troublesome symptoms that affected their daily life.

"Our findings suggest that a large proportion of patients with negative results from pH monitoring studies continue PPI therapy despite evidence contradicting the presence of GERD," the authors write. "In addition, most patients did not recall being counseled to stop their PPI, and such counsel was not documented in the majority of patients' medical records."

Two authors disclosed to the pharmaceutical and medical device industries.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Oral contraceptive equal to antibiotics for acne care

1 hour ago

(HealthDay)—At six months, oral contraceptive pills (OCPs) are comparable to systemic antibiotics for acne management, according to a review published in the September issue of the Journal of the American Ac ...

Photodynamic therapy vs. cryotherapy for actinic keratoses

2 hours ago

Photodynamic therapy (PDT, which uses topical agents and light to kill tissue) appears to better clear actinic keratoses (AKs, a common skin lesion caused by sun damage) at three months after treatment than cryotherapy (which ...

US official warns Ebola outbreak will get worse

4 hours ago

A third top doctor has died from Ebola in Sierra Leone, a government official said Wednesday, as a leading American health official warned that the outbreak sweeping West Africa would get worse before it ...

UN releases $1.5mn to help DR Congo fight Ebola

6 hours ago

The United Nations on Wednesday allocated $1.5 million (1.1 million euros) to help the Democratic Republic of Congo fight Ebola, just days after the country confirmed its first cases this year.

User comments