Pre-op breast pain in about 28 percent of breast cancer patients

June 15, 2012
Pre-op breast pain in about 28 percent of breast cancer patients
More than a quarter of women about to undergo breast cancer surgery experience breast pain, with genetic polymorphisms in inflammatory cytokines correlating with pain, according to a study published in the May issue of The Journal of Pain.

(HealthDay) -- More than a quarter of women about to undergo breast cancer surgery experience breast pain, with genetic polymorphisms in inflammatory cytokines correlating with pain, according to a study published in the May issue of The Journal of Pain.

Birha McCann, R.N., C.N.S., of the University of California in San Francisco, and associates recruited 398 women with breast cancer prior to surgery to determine the occurrence rate and characteristics of preoperative breast pain. The women completed self-report questionnaires and were genotyped. Variations in pro- and anti-inflammatory cytokine genes were assessed for those who did and did not report pain.

The researchers found that 28.2 percent of women self-reported breast pain. These women were significantly younger (P < 0.001), were more likely to be nonwhite (P = 0.032), were less likely to be postmenopausal (P = 0.012), reported lower Karnofsky Performance Status scores (P = 0.008), and had undergone more biopsies (P = 0.006). Presurgical breast pain was significantly less likely for carriers of the minor allele for a single nucleotide polymorphism in interleukin (IL)1-receptor 1 and significantly more likely for carriers of the minor allele of a single nucleotide polymorphism in IL13.

"Findings suggest that breast pain occurs in over a quarter of women who are about to undergo ," the authors write. "Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative ."

Explore further: A third of women with secondary breast cancer are needlessly living in pain, research shows

More information: Abstract
Full Text (subscription or payment may be required)


Related Stories

Recommended for you

Researchers develop method to map cancer progression

June 27, 2016

A team of scientists has developed a computational method to map cancer progression, an advance that offers new insights into the factors that spur this affliction as well as new ways of selecting effective therapies.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.