Reactive hypoglycemia symptoms improve with sitagliptin
The diabetes drug sitagliptin appears to reduce the severity of reactive hypoglycemia, a form of low blood sugar that occurs after a meal, a preliminary study finds. The results will be presented at The Endocrine Society's 94th Annual Meeting in Houston.
"Further studies may determine if it is possible to use sitagliptin as a novel approach to treat this condition, for which there currently is no medical therapy," said the lead investigator, Francisco Gomez-Perez, MD, of Instituto Nacional de Ciencias Medicas y Nutricion SZ in Mexico City.
Also called postprandial hypoglycemia, reactive hypoglycemia can occur in both diabetic and nondiabetic individuals, usually after eating carbohydrates, or sugars. Symptoms include anxiety, heart palpitations, tremor (shakiness), sweating, dizziness, tingling of the fingers, difficulty concentrating and weakness. Current treatment, which is not always successful, involves avoiding high-sugar foods and eating small portions throughout the day, Gomez-Perez said.
The presumed cause of reactive hypoglycemia is a delayed secretion of the hormone insulin in response to ingested carbohydrates, he said. Insulin is needed at the right time to take care of the rise in blood sugar that usually follows a meal.
Doctors prescribe sitagliptin (marketed as Januvia) to lower glucose, or blood sugar, levels in adults with Type 2 diabetes. Gomez-Perez and his co-workers hypothesized that this medication might reduce the symptoms of reactive hypoglycemia.
In 28 people with reactive hypoglycemia (24 women and four men), the researchers studied the effects of taking either a 100-milligram tablet of sitagliptin once a day or an identical-appearing but inactive placebo ("dummy") pill. Thirteen participants randomly received sitagliptin, and the other 15 got the placebo. The authors received placebo and sitagliptin as well as funding for study materials from the manufacturer, Merck.
Before and after two weeks of treatment, participants had a five-hour meal tolerance test to measure their insulin and blood sugar levels. This test consisted of taking blood samples shortly before and repeatedly after the subjects ate a 440-calorie meal. It contained 100 grams of carbohydrates, an amount that would usually trigger symptoms of reactive hypoglycemia in these patients. The first 30 minutes of the test was the early phase, and the period from one to five hours made up the late phase.
Initial pretest insulin and glucose levels were similar between groups. In the late phase of the meal tolerance test, however, the group that received sitagliptin had significantly higher blood sugar levels, according to the abstract. This correlated with a reduced intensity of symptoms of low blood sugar. The sitagliptin-treated group reported that the intensity of their symptoms was much lower than that reported by the placebo group: 2 versus 5, respectively, on a scale of 0 to 10, with 0 indicating not present and 10 representing maximum intensity.
"Our results suggest that the reduction of hypoglycemia is related to an improvement in the secretion of insulin during the early phase of the meal tolerance test," Gomez-Perez said. "Sitagliptin appears to restore the normal dynamics of insulin secretion."
Although he called the results "promising," he said more research is necessary before they can recommend sitagliptin for treatment of reactive hypoglycemia.
Provided by The Endocrine Society
- Which diabetes drug is best for diabetics with kidney disease? Nov 13, 2011 | not rated yet | 0
- Be Aware of Blood Sugar Post Gastric Bypass Jan 04, 2010 | not rated yet | 0
- A diabetes drug, sitagliptin, also has a potential to prevent diabetes Mar 24, 2011 | not rated yet | 0
- Injected liraglutide is better than oral sitagliptin for blood glucose control in type 2 diabetes Apr 22, 2010 | not rated yet | 0
- Mothers' high blood sugar in pregnancy is linked to children's reduced insulin sensitivity Jun 22, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Solvability of a circuit
3 hours ago Let's say I have a circuit consisting only of a finite number of batteries and resistors, all ideal. Given an arbitrary shape of this circuit, will I...
Question about perception of colors around light sources
7 hours ago When I look at a distant light source (like car headlights, or street lamp lights) I notice colors of the visible spectrum (as separated (as in after...
Does a charged particle rotate when traveling through a static Bf?
8 hours ago I have been looking at mass spectrometers, in particular the interactions between the Bf ind of a charged particle in motion in a static Bf of the...
Find a link between physics and assignment problems
10 hours ago Hi ! I've been working about assignments problems and how to solve them. I will have to do a presentation about it in few weeks. However, I'll...
Light as a source of electricity
10 hours ago Hello Dear Fellows! We all know that light is an electromagnetic wave and also we know that an antenna receives EM waves and...
A question about the energy stored in a capacitor.
10 hours ago If we imagine a simple circuit with a battery and a capacitor with negligible internal resistance, the capacitor is charged up to a point where the...
- More from Physics Forums - Classical Physics
More news stories
(HealthDay)—Moderate aerobic exercise prevents fructose-induced hypertriglyceridemia in healthy males, according to a study published online May 14 in Diabetes.
Diabetes May 17, 2013 | 5 / 5 (1) | 0 |
A DNA variant near a digestive enzyme does not only affect risk of developing diabetes but also affects the response to treatment, an international consortium of researchers including the University of Dundee has found.
Diabetes May 17, 2013 | not rated yet | 0 |
(Medical Xpress)—Development of a sophisticated artificial pancreas holds potential to transform the lives of patients with Type 1 diabetes.
Diabetes May 16, 2013 | 5 / 5 (1) | 0 |
A small University at Buffalo study has found for the first time that in Type 1 diabetics, insulin injections exert a strong anti-inflammatory effect at the cellular and molecular level, while even small amounts of glucose ...
Diabetes May 16, 2013 | not rated yet | 0
(HealthDay)—Home diabetes regimens partially explain the increased risk of having a hypoglycemia event during hospitalization among older African-American men with diabetes, according to a study published ...
Diabetes May 14, 2013 | not rated yet | 0
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
9 hours ago | not rated yet | 0 |
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
10 hours ago | 5 / 5 (2) | 0 |
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
10 hours ago | 4.8 / 5 (4) | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
9 hours ago | 5 / 5 (2) | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
14 hours ago | not rated yet | 0
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
9 hours ago | not rated yet | 0