Skin testing not sufficient to ID contrast media sensitivity

June 1, 2012
Skin testing not sufficient to ID contrast media sensitivity
More than 50 percent of patients with nonimmediate reactions to iodinated contrast media are identified with the drug provocation test and not with skin testing, according to a study published online May 15 in Allergy.

(HealthDay) -- More than 50 percent of patients with nonimmediate reactions to iodinated contrast media (CM) are identified with the drug provocation test (DPT) and not with skin testing, according to a study published online May 15 in Allergy.

Maria J. Torres, M.D., Ph.D., of Carlos Haya Hospital in Malaga, Spain, and associates investigated the role of skin testing and the DPT in the diagnosis of nonimmediate reactions to CM in 161 patients. Skin intradermal and patch testing were performed with different CM. In cases with a negative skin test, a single-blind placebo-controlled DPT was performed.

The researchers found that 21.1 percent of the subjects were skin-test positive to the various CM. In 34.6 percent of skin-test negative cases the DPT was positive. Of the 78 cases with confirmed hypersensitivity, 56.4 percent were identified by DPT and 43.6 percent were identified by skin testing.

"We conclude that sensitivity is not sufficient and that, in more than 50 percent of cases, a DPT is also needed to establish the diagnosis," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

New insight into how the immune system sounds the alarm

August 3, 2015

T cells are the guardians of our bodies: they constantly search for harmful invaders and diseased cells, ready to swarm and kill off any threats. A better understanding of these watchful sentries could allow scientists to ...

How to become a T follicular helper cell

July 30, 2015

Follicular helper Tcells (TFH cells), a rare type of immune cell that is essential for inducing a strong and lasting antibody response to viruses and other microbes, have garnered intense interest in recent years but the ...

The role of the microbiota in preventing allergies

July 10, 2015

The human body is inhabited by billions of symbiotic bacteria, carrying a diversity that is unique to each individual. The microbiota is involved in many mechanisms, including digestion, vitamin synthesis and host defense. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.