Skin testing not sufficient to ID contrast media sensitivity

June 1, 2012
Skin testing not sufficient to ID contrast media sensitivity
More than 50 percent of patients with nonimmediate reactions to iodinated contrast media are identified with the drug provocation test and not with skin testing, according to a study published online May 15 in Allergy.

(HealthDay) -- More than 50 percent of patients with nonimmediate reactions to iodinated contrast media (CM) are identified with the drug provocation test (DPT) and not with skin testing, according to a study published online May 15 in Allergy.

Maria J. Torres, M.D., Ph.D., of Carlos Haya Hospital in Malaga, Spain, and associates investigated the role of skin testing and the DPT in the diagnosis of nonimmediate reactions to CM in 161 patients. Skin intradermal and patch testing were performed with different CM. In cases with a negative skin test, a single-blind placebo-controlled DPT was performed.

The researchers found that 21.1 percent of the subjects were skin-test positive to the various CM. In 34.6 percent of skin-test negative cases the DPT was positive. Of the 78 cases with confirmed hypersensitivity, 56.4 percent were identified by DPT and 43.6 percent were identified by skin testing.

"We conclude that sensitivity is not sufficient and that, in more than 50 percent of cases, a DPT is also needed to establish the diagnosis," the authors write.

Explore further: Objective evidence of skin infestation lacking in patients with diagnosis of delusional infestation

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Epigenomic changes are key to innate immunological memory

August 31, 2015

A research team led by Keisuke Yoshida and Shunsuke Ishii of the RIKEN Molecular Genetics Laboratory has revealed that epigenomic changes induced by pathogen infections, mediated by a transcription factor called ATF7, are ...

Team finds early inflammatory response paralyzes T cells

August 18, 2015

In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help ...

SIV shrugs off antibodies in vaccinated monkeys

August 11, 2015

New research on monkeys vaccinated against HIV's relative SIV calls into question an idea that has driven AIDS vaccine work for years. The assumption: a protective vaccine only needs to stimulate moderate levels of antibodies ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.