Skin testing not sufficient to ID contrast media sensitivity

Skin testing not sufficient to ID contrast media sensitivity
More than 50 percent of patients with nonimmediate reactions to iodinated contrast media are identified with the drug provocation test and not with skin testing, according to a study published online May 15 in Allergy.

(HealthDay) -- More than 50 percent of patients with nonimmediate reactions to iodinated contrast media (CM) are identified with the drug provocation test (DPT) and not with skin testing, according to a study published online May 15 in Allergy.

Maria J. Torres, M.D., Ph.D., of Carlos Haya Hospital in Malaga, Spain, and associates investigated the role of skin testing and the DPT in the diagnosis of nonimmediate reactions to CM in 161 patients. Skin intradermal and patch testing were performed with different CM. In cases with a negative skin test, a single-blind placebo-controlled DPT was performed.

The researchers found that 21.1 percent of the subjects were skin-test positive to the various CM. In 34.6 percent of skin-test negative cases the DPT was positive. Of the 78 cases with confirmed hypersensitivity, 56.4 percent were identified by DPT and 43.6 percent were identified by skin testing.

"We conclude that sensitivity is not sufficient and that, in more than 50 percent of cases, a DPT is also needed to establish the diagnosis," the authors write.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

New national study links asthma to allergies

date Sep 27, 2007

Researchers at the National Institutes of Health (NIH) have found that more than 50 percent of the current asthma cases in the country can be attributed to allergies, with approximately 30 percent of those cases attributed ...

Recommended for you

How to avoid July Fourth allergy flare-ups

date Jul 03, 2015

Fireworks, picnics and parades are favorite Fourth of July traditions for many people, but for those with allergies or asthma these activities could be uncomfortable or even dangerous.

Researchers discover the cause of coeliac disease

date Jun 30, 2015

Professor Ludvig M. Sollid and his colleagues at the University of Oslo have found the cause of coeliac disease. To do so required really going into depth, right down to molecular level. 

Mechanism of T cell self / non-self “education”

date Jun 30, 2015

Researchers at the University of Tokyo have demonstrated that a protease only found in the thymus produces special peptides that promote positive selection of T cells that can detect non-self antigens, a ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.