Testosterone overprescribed, particularly for older men
(Medical Xpress) -- Testosterone prescriptions have surged since 2006 due to promotional activity, according to University of Sydney research which also found growing overuse in older men.
The research by Professor David Handelsman from the University and director of the ANZAC Research Institute, Concord Hospital has been published today in the Medical Journal of Australia.
It follows another recent study, led by Professor Handelsman and published in the journal of Clinical Endocrinology, which suggests testosterone decline in older men is not a result of ageing but of medical conditions and ill health that accumulate as men get older.
"This Healthy Man Study looked at very healthy men aged 40 and over and found that a decrease in testosterone was not associated with increasing age. Instead factors such as obesity or a history of smoking were strongly linked with any decrease," Professor Handelsman said.
The study supported the interpretation that diseases associated with ageing and not ageing itself affects testosterone levels in older men. It underlines the inappropriateness of the increasing sales of testosterone to older men which is highlighted in Professor Handelsman's MJA article.
The study in the MJA analyses data from the Pharmaceutical Benefits Scheme and IMS, a company that provides national sales data year by year.
"I found that stable market growth over 15 years was disrupted by sharp increases following the introduction of two new testosterone products - a gel and a long-acting injectable version by a single company which became a monopoly supplier," Professor Handelsman said.
"There is growing overuse of testosterone in older men as an anti-ageing tonic and non-specific treatment for sexual dysfunction, for which sound evidence is lacking. Yet at the same time genuine low-testosterone conditions due to diseases of the reproductive system remain underdiagnosed."
At present new uses of testosterone should be restricted to carefully designed clinical trials to determine whether there is any objective benefit from testosterone treatment for conditions such as obesity, diabetes or cardiovascular diseases that accumulate as men age, Professor Handelsman observed.
"The progressive increase appears to be due to promotion-driven marketing of products which do not comply with the Pharmaceutical Benefits Scheme prescribing criteria and suggest that more effective implementation of those criteria is needed."
Provided by University of Sydney
- Older age does not cause testosterone levels to decline in healthy men Jun 07, 2011 | not rated yet | 0
- Study refutes testosterone as 'fountain of youth' Oct 21, 2011 | not rated yet | 0
- Older men with higher testosterone levels lose less muscle mass as they age Oct 27, 2011 | not rated yet | 0
- Low testosterone appears to increase long-term risk of death Jun 17, 2008 | not rated yet | 0
- Study of testosterone in older men Nov 12, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
May 23, 2013 Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
Medical research May 23, 2013 | 5 / 5 (1) | 0 |
Aortic arch pulse wave velocity, a measure of arterial stiffness, is a strong independent predictor of disease of the vessels that supply blood to the brain, according to a new study published in the June issue the journal ...
Medical research May 23, 2013 | not rated yet | 0
Since the discovery of Prontosil in 1932, sulfonamide antibiotics have been used to combat a wide spectrum of bacterial infections, from acne to chlamydia and pneumonia. However, their side effects can include serious neurological ...
Medical research May 23, 2013 | 3 / 5 (1) | 0 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
Medical research May 23, 2013 | 5 / 5 (3) | 0 |
Spanish researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today ...
Medical research May 23, 2013 | 5 / 5 (2) | 0
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
19 hours ago | 5 / 5 (5) | 5
(HealthDay)—Animals make great companions for senior citizens, but elderly people who always drive with a pet in the car are far more likely to crash than those who never drive with a pet, researchers have ...
11 hours ago | not rated yet | 1
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
19 hours ago | 5 / 5 (1) | 1
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
May 20, 2013 | 4.8 / 5 (31) | 9 |
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
19 hours ago | not rated yet | 0
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
19 hours ago | not rated yet | 0